1201629-58-4Relevant academic research and scientific papers
Pyranocoumarins: A new class of anti-hyperglycemic and anti-dyslipidemic agents
Kumar, Atul,Maurya, Ram Awatar,Sharma, Siddharth,Ahmad, Pervez,Singh,Bhatia, Gitika,Srivastava, Arvind K.
supporting information; experimental part, p. 6447 - 6451 (2010/05/02)
A series of pyranocoumarin derivatives were synthesized and evaluated in vivo for their anti-hyperglycemic as well as anti-dyslipidemic activities. Compounds 7a, 7c, 8a, 8b, 8c, 8e and 8f have shown promising anti-hyperglycemic activities in sucrose loaded model (SLM) as well as sucrose challenged streptozotocin induced diabetic rat model (STZ). Compounds 8a and 8b were showing 38.0% and 42.0% blood glucose lowering activity in db/db mice model. In vitro anti-hyperglycemic activity evaluation exhibited that compounds 8a (IC50 = 24.5 μM) and 8b (IC50 = 36.2 μM) are potential PTP-1B inhibitors thereby revealing their possible mechanism of anti-diabetic action. Compounds 7a, 7b, 8a, 8b, 8d, 8e and 8f have shown significant anti-dyslipidemic activity in triton induced dyslipidemia in rats.
