1201633-86-4

Upstream product

• 26670-89-3 2-bromo-4-iodo-1-methylbenzene 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 1201633-89-7 C₁₃H₁₆BrNOS 
• 40180-80-1 3-bromo-4-methylacetophenone 
• 64-17-5 ethanol 
• 1201633-84-2 2-(3-bromo-4-methylphenyl)acetic acid 

Downstream Products

• 208989-24-6 1-bromo-2-(4-methyl-3-pentylphenyl)ethane 
• 1201633-85-3 2-(3-Bromo-4-methylphenyl)ethanol 
• 1201633-88-6 2-(4-methyl-3-pentylphenyl)ethanol 

Relevant academic research and scientific papers

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

A practical synthesis of α-haloaryl esters has been achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatsky reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chemistry tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by ethyl 2-(4-bromo-2-chlorophenyl)acetate (3a), can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters.

PHENYL-ALKYL PIPERAZINES HAVING TNF-MODULATING ACTIVITY, PREPARATION METHOD, AND THERAPEUTIC USE THEREOF

The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the preparation thereof, pharmaceutical compositions thereof, and to t