1201666-82-1Relevant academic research and scientific papers
Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction
Bertrand, Hélène C.,Schaap, Marjolein,Baird, Liam,Georgakopoulos, Nikolaos D.,Fowkes, Adrian,Thiollier, Clarisse,Kachi, Hiroko,Dinkova-Kostova, Albena T.,Wells, Geoff
, p. 7186 - 7194 (2015/10/05)
The transcription factor Nrf2 regulates the expression of a large network of cytoprotective and metabolic enzymes and proteins. Compounds that directly and reversibly inhibit the interaction between Nrf2 and its main negative regulator Keap1 are potential pharmacological agents for a range of disease types including neurodegenerative conditions and cancer. We describe the development of a series of 1,4-diphenyl-1,2,3-triazole compounds that inhibit the Nrf2-Keap1 protein-protein interaction (PPI) in vitro and in live cells and up-regulate the expression of Nrf2-dependent gene products.
Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues
Berger, Olivier,Kaniti, Archana,van Ba, Christophe Tran,Vial, Henri,Ward, Stephen A.,Biagini, Giancarlo A.,Bray, Patrick G.,O'Neill, Paul M.
, p. 2094 - 2108 (2012/06/18)
Four different series of triazole diamidines have been prepared by the Pinner method from the corresponding triazole dinitriles. Copper-catalyzed "click chemistry" was used for the synthesis of 1,4- and 4,5-substituted triazoles, aryl magnesium acetylide
TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
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Page/Page column 10, (2011/06/24)
This invention relates to novel triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders a
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3- triazoles
Bakunov, Stanislav A.,Bakunova, Svetlana M.,Wenzler, Tanja,Ghebru, Maedot,Werbovetz, Karl A.,Brun, Reto,Tidwell, Richard R.
experimental part, p. 254 - 272 (2010/05/02)
Novel dicationic triazoles 1-60 were synthesized by the Pinner method from the corresponding dinitriles, prepared via the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The type and the placement of cationic moieties as well as the nature of arom
