1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-dimethylethyl ester
CAS No.:1201676-05-2
Molecular Formula:C16H21ClN4O3
Molecular Weight:352.821
Hs Code.:
Mol file:1201676-05-2.mol

Synonyms:4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)-piperazine-1-carboxylic acid tert-butyl ester;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-dimethylethyl ester

Chemical Property:

PSA：74.77000
LogP:2.36720

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-dimethylethyl ester

There total 3 articles about 1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1201676-03-0
4,6-dichloro-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1201676-04-1
4-(6-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1201676-05-2
4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; at 120 ℃; for 40h; Sealed tube;
DOI:10.1021/jm100076w

Reference yield:

: 1201676-02-9
3-bromomethyl-2,6-dichloroisonicotinic acid ethyl ester

: 1201676-05-2
4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / tetrahydrofuran / 18 h / 20 °C

2: triethylamine / 1,4-dioxane / 40 h / 120 °C

With ammonium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 137520-99-1
2,6-dichloro-3-methylisonicotinic acid ethyl ester

: 1201676-05-2
4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; acetic acid; dibenzoyl peroxide / tetrachloromethane / 5 h / 60 °C

2: ammonium hydroxide / tetrahydrofuran / 18 h / 20 °C

3: triethylamine / 1,4-dioxane / 40 h / 120 °C

With ammonium hydroxide; N-Bromosuccinimide; acetic acid; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane;