1201683-60-4Relevant academic research and scientific papers
Multiple-turnover isotopic labeling of Fmoc- and boc-protected amino acids with oxygen isotopes
Seyfried, Martin S.,Lauber, Birgit S.,Luedtke, Nathan W.
, p. 104 - 106 (2010)
Chemical Equation Presented An efficient method for the selective isotopic labeling of carboxylic acids is reported. By reacting an amino acid with excess carbodiimide and 18OH2, a kinetically enhanced multiple turnover reaction provides the 18O-labeled product in high yield and excellent isotopic enrichment. This reaction is fully compatible with standard Fmoc, Boc, Trt, and OtBu protecting groups and provides a means to selectively label the α-carboxylic acids of functionalized amino acids with stable oxygen isotopes
