1201687-01-5

Basic information

• Product Name: (3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]pyrazolidine-3-carboxamide
• CAS NO: 1201687-01-5
• Molecular Weight: 421.887
• Mol File: 1201687-01-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]pyrazolidine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]pyrazolidine-3-carboxamide(1201687-01-5)
• EPA Substance Registry System: (3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]pyrazolidine-3-carboxamide(1201687-01-5)

Safety Data

• Hazardous Substances Data: 1201687-01-5(Hazardous Substances Data)

Upstream product

• 449756-95-0 5-Chloro-2-tetrazol-1-yl-benzylamine 
• 22146-57-2 (2R)-3,3-Dimethyl-2-hydroxybutyric acid 

Relevant articles and documents

Discovery of AZD8165 - A clinical candidate from a novel series of neutral thrombin inhibitors

A novel series of neutral thrombin inhibitors has been developed using a selection process based on docking experiments and property calculations and predictions. This work resulted in the identification of the highly potent thrombin inhibitor compound 85 (Ki = 300 pM) and the corresponding propionate prodrug 5 (AZD8165) as a candidate for clinical evaluation in the treatment of thrombosis and related diseases. AZD8165 was found to be safe and well tolerated and delivered the expected pharmacological response in a phase I trial in healthy male volunteers.