22146-57-2

Basic information

• Product Name: (R)-Trimethyllactic acid
• Synonyms: (R)-(-)-3,3-Dimethyl-2-hydroxybutyric acid;(R)-2-Hydroxy-3,3-dimethylbutanoic acid;(R)-Trimethyllactic acid;(2R)-2-Hydroxy-3,3-dimethylbutanoic acid;[R,(-)]-2-Hydroxy-3,3-dimethylbutyric acid
• CAS NO: 22146-57-2
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.16
• Mol File: 22146-57-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 242 ºC
• Flash Point: 115 ºC
• Appearance: /
• Density: 1.100
• Vapor Pressure: 0.00583mmHg at 25°C
• Refractive Index: 1.459
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-Trimethyllactic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Trimethyllactic acid(22146-57-2)
• EPA Substance Registry System: (R)-Trimethyllactic acid(22146-57-2)

Safety Data

• Hazardous Substances Data: 22146-57-2(Hazardous Substances Data)

Usage

General Description

"(R)-Trimethyllactic acid, also known as LACTIC ACID, TRIMETHYL-, (R)-, is a chemical compound with the formula C6H12O3. It has a molecular weight of 132.16 g/mol. This chemical is characterized as an organic compound belonging to the class of organic compounds known as alpha hydroxy acids and derivatives. These are compounds containing an aldehyde substituted with a hydroxyl group on the adjacent carbon. It exists as a colorless liquid and has a slight vinegar-like odor. It is primarily used in chemical and pharmaceutical applications.

InChI:InChI=1/C6H12O3/c1-6(2,3)4(7)5(8)9/h4,7H,1-3H3,(H,8,9)/t4-/m0/s1

Upstream product

• 815-17-8 trimethylpyruvic acid 
• 346424-16-6 (2R)-ethyl 2-hydroxy-3,3-dimethylbutanoate 
• 20859-02-3 L-tert-Leucine 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 26782-71-8 D-tert-leucine 
• 5333-74-4 ethyl 3,3-dimethyl-2-oxobutanoate 
• 30263-65-1 1,1-dibromo-3,3-dimethylbutan-2-one 

Downstream Products

• 486394-64-3 [4-Chloro-2-({[(S)-1-((R)-2-hydroxy-3,3-dimethyl-butyryl)-azetidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 439117-45-0 [4-Chloro-2-({[(S)-1-((R)-2-hydroxy-3,3-dimethyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 1201687-01-5 (3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]pyrazolidine-3-carboxamide 
• 1201686-89-6 (3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]isoxazolidine-3-carboxamide 
• 1097134-05-8 (1S,5R)-N-[[5-chloro-2-(tetrazol-1-yl)phenyl]methyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]-2-azabicyclo[3.1.0]hexane-1-carboxamide 
• 1097133-03-3 (1R,2S,5S)-3-((R)-2-hydroxy-3,3-dimethylbutyryl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide 
• 1097132-93-8 (1S,2S,5R)-3-((R)-2-hydroxy-3,3-dimethylbutyryl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide 
• 1097133-07-7 (1S,3S,5S)-2-((R)-2-hydroxy-3,3-dimethylbutyryl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide 
• 1097133-05-5 (1R,3S,5R)-2-((R)-2-hydroxy-3,3-dimethylbutyryl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide 
• 1201686-64-7 (5S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-1-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]-4,5-dihydro-1H-pyrazole-5-carboxamide 
• 1462904-38-6 C₁₉H₂₈ClN₃O₅S*C₂HF₃O₂ 
• 1462904-36-4 C₁₉H₂₈ClN₃O₄S*C₂HF₃O₂ 
• 1462904-34-2 C₁₉H₂₈ClN₃O₃S*C₂HF₃O₂ 
• 1462904-32-0 C₁₉H₂₈ClN₃O₄*C₂HF₃O₂ 

Relevant articles and documents

Asymmetric hydrogenation reaction of alpha-ketoacids compound

The invention relates to the technical field of organic chemistry, especially to an asymmetric hydrogenation reaction of an alpha-ketoacids compound. The asymmetric hydrogenation reaction comprises a scheme shown in the description. In the scheme, R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, C1-C6 alkyl, or aralkyl; a substituent group is C1-C6 alkyl, C1-C6 alkoxy, or halogen; and the number of the substituent group is 1-3. In the scheme, M is a chiral spiro-pyridylamino phosphine ligand iridium complex having a structure shown in the description. In the structure, R is hydrogen, 3-methyl, 4-tBu, or 6-methyl.

Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts

A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.

Stereoselective synthesis of a potent thrombin inhibitor by a novel P2-P3 lactone ring opening

The concise synthesis of a potent thrombin inhibitor was accomplished by a mild lactone aminolysis between an orthogonally protected bis-benzylic amine and a diastereomerically pure lactone. The lactone was synthesized by the condensation of L-proline met