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1201687-09-3

tert-butyl (3S)-3-{[5-chloro-2-(1H-tetrazol-1-yl)benzyl]carbamoyl}isoxazolidine-2-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1201687-09-3 Structure

  • Basic information

    1. Product Name: tert-butyl (3S)-3-{[5-chloro-2-(1H-tetrazol-1-yl)benzyl]carbamoyl}isoxazolidine-2-carboxylate
    2. Synonyms: tert-butyl (3S)-3-{[5-chloro-2-(1H-tetrazol-1-yl)benzyl]carbamoyl}isoxazolidine-2-carboxylate
    3. CAS NO:1201687-09-3
    4. Molecular Formula:
    5. Molecular Weight: 408.845
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1201687-09-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: tert-butyl (3S)-3-{[5-chloro-2-(1H-tetrazol-1-yl)benzyl]carbamoyl}isoxazolidine-2-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: tert-butyl (3S)-3-{[5-chloro-2-(1H-tetrazol-1-yl)benzyl]carbamoyl}isoxazolidine-2-carboxylate(1201687-09-3)
    11. EPA Substance Registry System: tert-butyl (3S)-3-{[5-chloro-2-(1H-tetrazol-1-yl)benzyl]carbamoyl}isoxazolidine-2-carboxylate(1201687-09-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1201687-09-3(Hazardous Substances Data)

1201687-09-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1201687-09-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,1,6,8 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1201687-09:
(9*1)+(8*2)+(7*0)+(6*1)+(5*6)+(4*8)+(3*7)+(2*0)+(1*9)=123
123 % 10 = 3
So 1201687-09-3 is a valid CAS Registry Number.

1201687-09-3Relevant articles and documents

Discovery of AZD8165 - A clinical candidate from a novel series of neutral thrombin inhibitors

Abrahamsson,Andersson,Bergman,Bredberg,Br?nalt,Egnell,Eriksson,Gustafsson,Hoffman,Nielsen,Nilsson,Pehrsson,Polla,Skjaeret,Strimfors,Wern,?lweg?rd-Halvarsson,?rtengren

supporting information, p. 272 - 281 (2016/03/01)

A novel series of neutral thrombin inhibitors has been developed using a selection process based on docking experiments and property calculations and predictions. This work resulted in the identification of the highly potent thrombin inhibitor compound 85 (Ki = 300 pM) and the corresponding propionate prodrug 5 (AZD8165) as a candidate for clinical evaluation in the treatment of thrombosis and related diseases. AZD8165 was found to be safe and well tolerated and delivered the expected pharmacological response in a phase I trial in healthy male volunteers.

Novel Compounds 148

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Page/Page column 25, (2009/12/28)

This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containi

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