1372202-46-4 Usage
Uses
Used in Pharmaceutical Research:
(S)-2-(tert-butoxycarbonyl)isoxazolidine-3-carboxylic acid is used as a precursor in the synthesis of bioactive molecules for pharmaceutical research. Its unique functional groups and stereochemistry contribute to the development of new drug candidates.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-2-(tert-butoxycarbonyl)isoxazolidine-3-carboxylic acid is used as a versatile building block for the preparation of diverse compounds, including amino acids, peptides, and pharmaceutical intermediates. Its Boc protecting group allows for selective reactions and the synthesis of complex molecular structures.
Used in Drug Design:
(S)-2-(tert-butoxycarbonyl)isoxazolidine-3-carboxylic acid is utilized in drug design due to its stereochemistry and functional groups, which are essential for the creation of new drug candidates with specific biological activities and improved pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1372202-46-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,2,2,0 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1372202-46:
(9*1)+(8*3)+(7*7)+(6*2)+(5*2)+(4*0)+(3*2)+(2*4)+(1*6)=124
124 % 10 = 4
So 1372202-46-4 is a valid CAS Registry Number.
1372202-46-4Relevant articles and documents
Improved synthesis of (S)-N-Boc-5-oxaproline for protein synthesis with the α-ketoacid-hydroxylamine (KAHA) ligation
Murar, Claudia E.,Harmand, Thibault J.,Bode, Jeffrey W.
, p. 4996 - 5001 (2017)
We describe a new route for the synthesis of (S)-N-Boc-5-oxaproline. This building block is a key element for the chemical synthesis of proteins with the α-ketoacid-hydroxylamine (KAHA) ligation. The new synthetic pathway to the enantiopure oxaproline is
Chemical protein synthesis by chemoselective α-ketoacid-hydroxylamine (KAHA) ligations with 5-oxaproline
Pattabiraman, Vijaya R.,Ogunkoya, Ayodele O.,Bode, Jeffrey W.
, p. 5114 - 5118 (2012/07/14)
The chemical synthesis of proteins from unprotected peptide segments uses KAHA ligation with 5-oxaproline, which is incorporated readily into peptides by solid-phase peptide synthesis. Ligation of such protein segments in aqueous buffers with an α-ketoacid peptide gives an α-homoserine residue at the ligation site. The new ligation is used for the synthesis of two proteins, prokaryotic-ubiquitin like protein (Pup) and probable cold shock protein A (cspA; see scheme). Copyright
