1201762-33-5Relevant academic research and scientific papers
An efficient asymmetric hydrophosphonylation of unsaturated amides catalyzed by rare-earth metal amides [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 with phenoxy-functionalized chiral prolinols
Fei, Zenghui,Zeng, Chao,Lu, Chengrong,Zhao, Bei,Yao, Yingming
, p. 19306 - 19311 (2017/04/11)
An asymmetric hydrophosphonylation reaction of diethyl phosphite with α,β-unsaturated amides catalyzed by [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 (RE = Sc (1), Y (2), La (3), Yb (4) and Lu (5)) with H2Ln ((S)-2,4-R2-6-[[2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]methyl]phenol) (R = tBu (H2L1); R = 1-cumyl (H2L2) and R = 1-adm (H2L3)) was disclosed. The effects of different central metals and proligands on the addition reaction were tested and it was found that the combination of Sc complex 1 and ligand H2L2 gave the best results. An excellent chemical yield (up to 99%) and good to high enantioselectivities (varied from 73 to 89%) were achieved with a relatively broad scope of the unsaturated amides. The active species in the current system was also discussed.
Highly enantioselective conjugate additions of phosphites to α β-unsaturated N-acylpyrroles and imines: A practical approach to enantiomerically enriched amino phosphonates3
Zhao, Depeng,Wang, Yuan,Mao, Lijuan,Wang, Rui
supporting information; experimental part, p. 10983 - 10987 (2010/04/30)
The first highly enantioselective phosphonylation of αβ- unsaturated N-acylpyrroles has been developed. Excellent yields (91-99%) and enantioselectivities (up to >99% enantiomeric excess (ee)) were observed for a broad spectrum of both phosphites and N-ac
