1201762-07-3Relevant academic research and scientific papers
Azetidine-derived dinuclear zinc catalyzed asymmetric phospha-Michael addition of dialkyl phosphite to α,β-unsaturated carbonyl compounds
Liu, Shanshan,Shao, Na,Li, Feng-Zhen,Yang, Xiao-Chao,Wang, Min-Can
, p. 9465 - 9474 (2017/11/22)
The asymmetric phospha-Michael addition of dialkyl phosphite to α,β-unsaturated carbonyl compounds by using an azetidine-derived dinuclear zinc catalyst was described. The catalyst was proved to be general and efficient for a broad spectrum of enones and α,β-unsaturated N-acylpyrroles. A series of phosphonate-containing compounds were generated with excellent enantioselectivities (up to 99% ee) and chemical yields (up to 99%) under mild conditions without using additives. The products were obtained with more than 95% ee for 23 examples of α,β-unsaturated carbonyl compounds. A positive nonlinear effect was observed and the possible mechanism was proposed.
Highly enantioselective conjugate additions of phosphites to α β-unsaturated N-acylpyrroles and imines: A practical approach to enantiomerically enriched amino phosphonates3
Zhao, Depeng,Wang, Yuan,Mao, Lijuan,Wang, Rui
supporting information; experimental part, p. 10983 - 10987 (2010/04/30)
The first highly enantioselective phosphonylation of αβ- unsaturated N-acylpyrroles has been developed. Excellent yields (91-99%) and enantioselectivities (up to >99% enantiomeric excess (ee)) were observed for a broad spectrum of both phosphites and N-ac
