1201787-20-3

Upstream product

• 1201787-19-0 3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyridin-3-yl)-9H-pyrrolo-[2,3-b:5,4-c']dipyridine 
• 1201786-84-6 3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1201788-08-0 4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}aniline 
• 1201788-14-8 4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyaniline 
• 1331786-48-1 C₂₇H₂₁FN₄O₄S 
• 1201787-21-4 3-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]benzenesulfonamide 
• 1201788-12-6 N-(4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}phenyl)cyclopropanesulfonamide 
• 1201788-11-5 N-{-4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]phenyl}cyclopropanesulfonamide 
• 1201788-15-9 N-(4-{3-fluoro-9-[(4-methylphenyl)sulfonyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl}-2-methoxyphenyl)methanesulfonamide 
• 1201788-13-7 N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]-2-methoxyphenyl}methanesulfonamide 
• 1201788-16-0 N-{-4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]phenyl}-N-methylmethanesulfonamide 
• 1201788-18-2 N-[3-(dimethylamino)propyl]-N-{4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]phenyl}methanesulfonamide 
• 1201789-42-5 3-{-4-[3-fluoro-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-4-yl]phenoxy}-N,N-dimethylpropan-1-amine 
• 1246433-63-5 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-benzoic acid 
• 1246433-64-6 4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]-N-(4-methylpiperazin-1-yl)benzamide 
• 1246433-65-7 N-[2-(dimethylamino)ethyl]-4-[3-fluoro-6-(pyridin-3-yl)-9H-pyrrolo-[2,3-b:5,4-c']dipyridin-4-yl]benzamide 

Relevant academic research and scientific papers

9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF

The invention relates to novel 9H-pyrrolo[2,3-b:5,4-c′]dipyridine azacarbolines of formula (I), where: Z2, Z3, and Z4 are CH, CRa, CRs, or N; R3 is H, Hal; CF3, CHF2; OH, alkoxy; NH2, NH (alkyl), N(alkyl)2; C(O)O alkyl; CONH(alkyl), CON(alkyl)2; C1-C10 alkyl; aryl; heteroaryl; R6 is heteroaryl; Ra is CONH2, CONH alkyl, CONH cycloalkyl; CONH heterocycloalkyl; CON(alkyl)2; CON(alkyl)(heterocycloalkyl); CONHN(alkyl)2; C(O)heterocycloalkyl; Rs is H; Hal, OH; O-alkyl(C1-C10); NH2; N(alkyl(C1-C10) or cycloalkyl(C3-C7))2; NHC(O)R3a; N(alkyl(C1-C10)C(O)R3a; NHS(O2)R3a; N(alkyl)(C1-C10)S(O2)R3a; CO2R3a; SR3a; S(O)R3a; S(O2)R3a; Ra and Rs optionally form a cycle; R3a is selected from among Hal, CF3, C1-C10 alkyl; C3-C7 cycloalkyl; C2-C6 alkenyl; C2-C6 alkynyl; OH; O-alkyl(C1-C10); (C3-C7); heterocycloalkyl (C3-C7); NH2; NH-(alkyl(C1-C10) or cycloalkyl(C3-C7)); N(alkyl(C1-C10) or cycloalkyl(C3-C7))2; NH-(alkyl(C1-C10) or heterocycloalkyl(C3-C7)); N(alkyl(C1-C10) or heterocycloalkyl(C3-C7))2, as well as to the isomers and salts of said substances of formula (I) and to the therapeutic use thereof for treating cancer.

AZACARBOLINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME

The invention relates to novel azacarbonlines having formula (I), wherein: R3, R4 represent independently H; hal; CF3; substituted oxy, optionally substituted alkoxy; optionally substituted amino; substituted carbonyl; optionally substituted carboxyl; optionally substituted amide; sulphur, such as optionally substituted sulphones, sulphoxides or sulphides; linear, branched or cyclic C1-C10 alkyl optionally comprising an optionally substituted heteroatom; optionally substituted linear, branched or cyclic C2-C7 alkenyl; optionally substituted linear or branched C2-C6 alkynyl; optionally substituted aryl or heteroaryl; of which may be optionally substituted; in the form of a base or an acid addition salt. The invention also relates to the use of same in therapeutics for the treatment of cancer and to synthesis methods.