1201849-59-3Relevant academic research and scientific papers
IRREVERSIBLE INHIBITORS USEFUL FOR THE TREATMENT OF KINASE-RELATED PATHOLOGIES
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Page/Page column 29-36, (2011/04/24)
The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer.
Synthesis of a Resorcylic Acid Lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases
Jogireddy, Rajamalleswaramma,Dakas, Pierre-Yves,Valot, Gaelle,Barluenga, Sofia,Winssinger, Nicolas
supporting information; experimental part, p. 11498 - 11506 (2010/05/02)
A library of resorcylic acid lactones (RAL) containing a cis-enone moiety targeting kinases bearing a cysteine residue within the ATP-binding pocket was prepared using a fluorous-mixture synthesis and evaluated against a panel of 19 kinases thus providing important structure-activity trends. Two new analogues were then profiled for their selectivity against a panel of 402 kinases providing the broadest evaluation of this pharmacophores' selectivity.
