1201901-49-6Relevant articles and documents
Chiral primary amine catalyzed asymmetric epoxidation of α-substituted acroleins
Li, Jiuyuan,Fu, Niankai,Zhang, Long,Zhou, Pengxin,Luo, Sanzhong,Cheng, Jin-Pei
, p. 6840 - 6849 (2011/03/19)
1,1-Disubstituted terminal alkenes remain challenging substrates in asymmetric epoxidation reactions. In this study, chiral primary amines are shown to catalyze the asymmetric epoxidation of α-substituted acroleins, a versatile type of 1,1-disubstituted t
Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors
Russo, Francesco,W?ngsell, Fredrik,S?vmarker, Jonas,Jacobsson, Micael,Larhed, Mats
experimental part, p. 10047 - 10059 (2010/02/28)
BACE-1 has emerged as one of the best characterized targets for future Alzheimer therapy. In accordance with the successful identification of masked inhibitors of HIV-1 protease, we envisioned that tert-alcohol containing transition-state mimicking struct