1201908-67-9Relevant academic research and scientific papers
MONOFLUORINATED DERIVATIVES OF DIANHYDROHEXITOLS AND PROCESSES FOR MAKING THE SAME
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Paragraph 0046; 0047, (2014/01/08)
Novel monofluoro analogs of isosorbide, isomannide and isoidide are described, together with processes for making such monofluoro analogs.
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability
Dillon, Gerald P.,Gaynor, Joanne M.,Khan, Denise,Carolan, Ciaran G.,Ryder, Sheila A.,Marquez, Juan F.,Reidy, Sean,Gilmer, John F.
experimental part, p. 1045 - 1053 (2010/04/26)
Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer's Disease (AD). They are stable in human plasma but in mouse plasma they undergo hydrolysis at the 5-ester group potentially attenuating in vivo potency. In this paper we explore the role of the 5-position in modulating potency. The focus of the study was to increase metabolic stability while preserving potency and selectivity. Dicarbamates and 5-keto derivatives were markedly less potent than the ester class. The 2-benzylcarbamate-5-benzyl ether was found to be potent (IC50 52 nM) and stable in the presence of mouse plasma and liver homogenate. The compound produces sustained moderate inhibition of mouse butyrylcholinesterase at 1 mg/kg, IP.
Copper-Catalyzed vs thermal step growth polymerization of starch-derived α-w-alkyne dianhydrohexitol stereoisomers: to click or not to click?
Besset, Celine,Binauld, Sandra,Ibert, Mathias,Fuertes, Patrick,Pascault, Jean-Pierre,Fleury, Etienne,Bernard, Julien,Drockenmuller, Eric
scheme or table, p. 17 - 19 (2011/09/14)
The synthesis of α-azide-ω-alkyne 1,4:3,6-dianhydrohexitols with controlled stereochemistry from starch-derived isosorbide, isomannide, and isoidide as well as a detailed study of their polyaddition by CuAAC in solution or by catalyst and solvent-free 1,3
Stereospecific method for the preparation of dioxa-bicyclooctane compounds
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Page/Page column 24, (2009/12/27)
This invention relates to a new method for the stereospecific thiocarboxylation of organic compounds for the preparation of compounds according to formula (I): wherein a compound of formula (II): is reacted with a compound of formula (IIIa) or (IIIb): the
