1201945-53-0

Basic information

• Product Name: C₂₂H₁₇FN₂O₂S
• Synonyms: C₂₂H₁₇FN₂O₂S
• CAS NO: 1201945-53-0
• Molecular Weight: 392.454
• Mol File: 1201945-53-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₇FN₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₇FN₂O₂S(1201945-53-0)
• EPA Substance Registry System: C₂₂H₁₇FN₂O₂S(1201945-53-0)

Safety Data

• Hazardous Substances Data: 1201945-53-0(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 1189207-30-4 4-fluoro-2-(phenyl ethynyl)benzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 1372206-28-4 butyl 8-fluoro-2-formyl-5-phenylpyrazolo[5,1-a]isoquinoline-1-carboxylate 
• 1372206-29-5 ethyl 2-acetyl-8-fluoro-5-phenylpyrazolo[5,1-a]isoquinoline-1-carboxylate 
• 1221497-70-6 1-ethyl-8-fluoro-5-phenyl-pyrazolo[5,1-a]isoquinoline 
• 1420779-58-3 8-fluoro-2-methyl-5-phenylpyrazolo[5,1-a]isoquinoline-1-carbaldehyde 
• 1400687-66-2 8-fluoro-2,5-diphenylpyrazolo[5,1-a]isoquinoline 
• 1379536-51-2 N-allyl-N-(8-fluoro-1,5-diphenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-66-9 N-allyl-N-(8-fluoro-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-65-8 N-allyl-N-(1-(4-chlorophenyl)-8-fluoro-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-63-6 N-allyl-N-(1-butyl-8-fluoro-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-64-7 N-allyl-N-(8-fluoro-1-(4-methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-71-6 N-(but-3-en-2-yl)-N-(8-fluoro-1,5-diphenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1379536-75-0 (E)-N-(but-2-en-1-yl)-N-(8-fluoro-1,5-diphenylpyrazolo[5,1-a]isoquinolin-2-yl)-4-methylbenzenesulfonamide 
• 1367861-27-5 ethyl 2-benzyl-8-fluoro-5-phenylpyrazolo[5,1-a]isoquinoline-1-carboxylate 
• 1367861-24-2 n-butyl 8-fluoro-2-methyl-5-phenylpyrazolo[5,1-a]isoquinoline-1-carboxylate 

Relevant articles and documents

Aryne [3 + 2] cycloaddition with N-sulfonylpyridinium imides and in situ generated N-sulfonylisoquinolinium imides: A potential route to pyrido[1,2-b]indazoles and indazolo[3,2-a]isoquinolines

The aryne [3 + 2] cycloaddition process with pyridinium imides breaks the aromaticity of the pyridine ring. By equipping the imide nitrogen with a sulfonyl group, the intermediate readily eliminates a sulfinate anion to restore the aromaticity, leading to the formation of pyrido[1,2-b]indazoles. The scope and limitation of this reaction are discussed. As an extension of this chemistry, N-tosylisoquinolinium imides, generated in situ from N′-(2-alkynylbenzylidene)-tosylhydrazides via an AgOTf-catalyzed 6-endo-dig electrophilic cyclization, readily undergo aryne [3 + 2] cycloaddition to afford indazolo[3,2-a]-isoquinolines in the same pot, offering a highly efficient route to these potential anticancer agents.

Synthesis of H-pyrazolo[5,1-a]isoquinolines via copper(II)-catalyzed oxidation of an aliphatic C-H bond of tertiary amine in air

A multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and tertiary amine is discovered, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good yields under mild conditions. In the reaction process, silver(I)-catalyzed intramolecular cyclization and copper(II)-catalyzed oxidation of an aliphatic C-H bond of tertiary amine in air are involved.