1202-32-0

Usage

Uses

Used in Chemical and Industrial Processes:
[(1E)-2-nitrobut-1-en-1-yl]benzene is used as an intermediate in the synthesis of various organic compounds, contributing to the development of new materials and products in the chemical industry. Its reactivity and structural features make it a versatile building block for creating a wide range of molecules with different applications.
Used in Organic Synthesis:
As a key component in organic synthesis, [(1E)-2-nitrobut-1-en-1-yl]benzene is utilized as a starting material for the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique combination of a nitro group and an alkene group allows for a range of reactions and transformations, leading to the creation of diverse chemical products.
Used in Research and Development:
In the field of research and development, [(1E)-2-nitrobut-1-en-1-yl]benzene serves as a valuable compound for studying the properties and reactivity of nitroalkenes. It can be used to explore new reaction mechanisms, develop innovative synthetic methods, and gain insights into the behavior of similar compounds.
Used in Pharmaceutical Industry:
[(1E)-2-nitrobut-1-en-1-yl]benzene is used as a building block for the development of new pharmaceuticals, particularly those targeting various diseases and conditions. Its unique structure allows for the creation of novel drug candidates with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical industry, [(1E)-2-nitrobut-1-en-1-yl]benzene is employed as a starting material for the synthesis of new pesticides, herbicides, and other crop protection agents. Its properties and reactivity enable the development of more effective and environmentally friendly products for agricultural use.

Upstream product

• 100-52-7 benzaldehyde 
• 108-03-2 1-Nitropropane 
• 62753-14-4 ((E)-1-Nitro-but-2-enyl)-benzene 
• 25236-40-2 1-nitro-1-phenylbut-1-ene 
• 62634-69-9 Acetic acid 1-(nitro-phenyl-methyl)-propyl ester 
• 100-46-9 benzylamine 

Downstream Products

• 109094-30-6 2-methyl-3-(2-nitro-1-phenyl-butyl)-indole 
• 1007-32-5 benzyl ethyl ketone 
• 61668-44-8 1-phenyl-2-nitrobutane 
• 1723-25-7 ethyl 2,3-dioxobutyrate 
• 95838-62-3 5-Ethyl-2-methyl-4-phenyl-3-pyrrolcarbonsaeure-ethylester 
• 91502-28-2 5-<(Acetyl)(methoxycarbonyl)methylenamino>-5-ethyl-4,5-dihydro-2-methyl-4-phenyl-3-furancarbonsaeure-methylester 
• 109632-31-7 2-oxo-1-phenylbutylphosphonate de diethyle 
• 701-70-2 1-phenyl-2-butanol 
• 1301127-18-3 diethyl (S)-3-ethyl-4-phenyl-4,5-dihydroisoxazole-5,5-dicarboxylate 2-oxide 
• 78156-62-4 1-phenyl-2-ethylnaphtho<2,1-b>furan 
• 1323976-17-5 (4-ethyl-3,5-diphenyl-1H-pyrrol-2-yl)(phenyl)methanone 

Relevant academic research and scientific papers

Substrate promiscuity of ortho-naphthoquinone catalyst: Catalytic aerobic amine oxidation protocols to deaminative cross-coupling and n-nitrosation

ortho-Naphthoquinone-based organocatalysts have been identified as versatile aerobic oxidation catalysts. Primary amines were readily cross-coupled with primary nitroalkanes via deaminative pathway to give nitroalkene derivatives in good to excellent yields. Secondary and tertiary amines were inert to ortho-naphthoquinone catalysts; however, secondary nitroalkanes were readily converted by ortho-naphthoquinone catalysts to the corresponding nitrite species that in situ oxidized the amines to the corresponding N-nitroso compounds. Without using harsh oxidants in a stoichiometric amount, the present catalytic aerobic oxidation protocol utilizes the substrate promiscuity feature to provide a facile access to amine oxidation products under mild reaction conditions.

Synthesis of Benzo[4,5]imidazo[2,1-b]thiazole by Copper(II)-Catalyzed Thioamination of Nitroalkene with 1H-Benzo[d]imidazole-2-thiol

A Copper(II)-catalyzed thioamination of β-nitroalkene with 1H-benzo[d]imidazole-2-thiol has been developed for the synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives. A variety of N-fused benzoimidazothiazole derivatives are obtained in high yields through successive C?N and C?S bond formations. This protocol is also applicable to β-substituted β-nitroalkenes to afford 2,3-disubstituted benzoimidazothiazoles. (Figure presented.).

Continuous-flow synthesis using a column reactor packed with heterogeneous catalysts: A convenient production of nitroolefins by using amino-functionalized silicagel

A continuous-flow synthesis of β-nitroolefins by using heterogeneous base catalysts has been developed. Although the use of an excess amount of nitro-donor such as nitromethane is required in conventional methods, nearly equimolar amounts of nitro-donors and carbonyl compounds are sufficient for high-yielding production of nitroolefins. Catalysts for this flow protocol are inexpensive and abundant, and high durability and high productivity were also realized by using an appropriate second support.

Iron-catalyzed tandem one-pot addition and cyclization of the blaise reaction intermediate and nitroolefins: Synthesis of substituted NH-pyrroles from nitriles

The iron-catalyzed addition and cyclization of the Blaise reaction intermediate and nitroolefins to synthesize highly functionalized NH-pyrroles in a tandem one-pot manner from nitriles has been developed. This reaction shows good functional group tolerance and affords a broad spectrum of substituted NH-pyrroles in good yields. Copyright

Minute synthesis of electrophilic alkenes under microwave irradiation

Condensation of carbonyl derivatives 2 with active methylene compounds 1 is efficiently achieved, within 3 to 15 minutes under microwave irradiation by a solvent free reaction in the presence of carefully adjusted amounts of piperidine leading to Knocvenagel products 3 in good to excellent yields.

Cathodic Reduction of 1-Nitroalkenes to Oximes and Primary Amines

1-Nitroalkenes are reduced in high yields at -0.3 to -0.5 V (vs.SCE) at a mercury or graphite cathode to oximes.At higher cathodic reduction potentials (-1.1 V) primary amines are selectively obtained in fair yields.Nitroalkadienes are selectively reduced at the double bond conjugated with the nitro group to either the oxime or amine.Key Words: Electrochemistry / 1-Nitroalkenes, reduction of / Oximes / Amines