1202-81-9

Basic information

• Product Name: 4-phenyltetrahydro-2H-pyran-4-carbonitrile
• Synonyms: 4-phenyltetrahydro-2H-pyran-4-carbonitrile;2H-pyran-4-carbonitrile, tetrahydro-4-phenyl-;4-phenyl-4-tetrahydropyrancarbonitrile;4-phenyloxane-4-carbonitrile;4-phenyltetrahydropyran-4-carbonitrile
• CAS NO: 1202-81-9
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.23772
• Mol File: 1202-81-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 49-50 °C
• Boiling Point: 339.6°C at 760 mmHg
• Flash Point: 143.3°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 9.09E-05mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 4-phenyltetrahydro-2H-pyran-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyltetrahydro-2H-pyran-4-carbonitrile(1202-81-9)
• EPA Substance Registry System: 4-phenyltetrahydro-2H-pyran-4-carbonitrile(1202-81-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1202-81-9(Hazardous Substances Data)

Usage

General Description

4-phenyltetrahydro-2H-pyran-4-carbonitrile is a chemical compound with the molecular formula C14H15NO, which belongs to the class of pyran derivatives. It is a colorless liquid with a molecular weight of 215.27 g/mol. 4-phenyltetrahydro-2H-pyran-4-carbonitrile is commonly used in organic synthesis and pharmaceutical research as a key intermediate in the production of various pharmaceuticals and agrochemicals. Its chemical structure contains a phenyl group and a carbonitrile group, and it is known for its ability to participate in numerous chemical reactions and form various derivatives. Additionally, it has potential biological activity and has been studied for its potential therapeutic properties in the treatment of various diseases.

InChI:InChI=1/C12H13NO/c13-10-12(6-8-14-9-7-12)11-4-2-1-3-5-11/h1-5H,6-9H2

Upstream product

• 140-29-4 phenylacetonitrile 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 14006-32-7 C-(4-phenyl-tetrahydro-pyran-4-yl)-methylamine 

Downstream Products

• 855628-79-4 1-(4-phenyl-tetrahydropyran-4-yl)-ethanone 
• 182491-21-0 4-phenyltetrahydro-2H-pyran-4-carboxylic acid 
• 100119-45-7 4-phenyltetrahydropyran-4-carbonyl chloride 
• 88782-31-4 4-phenyl-tetrahydro-pyran-4-carboxylic acid-(2-diethylamino-ethyl ester); hydrochloride 
• 20638-52-2 4-phenyltetrahydro-2H-pyran 
• 723272-14-8 4-bromo-2-(2-bromo-ethyl)-2-phenyl-butyric acid 
• 109188-31-0 5-(4-phenyl-tetrahydro-pyran-4-yl)-1⁽²⁾H-tetrazole 

Relevant articles and documents

Synthesis of nitriles from amines using nanoscale Co3O4-based catalysts via sustainable aerobic oxidation

The selective oxidation of amines for the benign synthesis of nitriles under mild conditions is described. Key to success for this transformation is the application of reusable cobalt oxide-based nanocatalysts. The resulting nitriles constitute key precursors and central intermediates in organic synthesis.

"Nanorust"-catalyzed benign oxidation of amines for selective synthesis of nitriles

Organic nitriles constitute key precursors and central intermediates in organic synthesis. In addition, nitriles represent a versatile motif found in numerous medicinally and biologically important compounds. Generally, these nitriles are synthesized by traditional cyanation procedures using toxic cyanides. Herein, we report the selective and environmentally benign oxidative conversion of primary amines for the synthesis of structurally diverse aromatic, aliphatic and heterocyclic nitriles using a reusable "nanorust" (nanoscale Fe2O3)-based catalysts applying molecular oxygen.