1202009-17-3Relevant articles and documents
Cyclohexylcarbonitriles: Diastereoselective arylations with TMPZnCl·LiCl
Mycka, Robert J.,Duez, Stephanie,Bernhardt, Sebastian,Heppekausen, Johannes,Knochel, Paul,Fleming, Fraser F.
, p. 7671 - 7676 (2012/10/30)
Deprotonating substituted cyclohexanecarbonitriles with TMPZnCl·LiCl affords zincated nitriles that diastereoselectively couple with aryl bromides in the presence of catalytic Pd(OAc)2 and S-Phos. Steric and electronic effects influence the dia