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CAS

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1202026-99-0

4-(6-Methoxypyridin-2-yl)benzotrifluoride is a synthetic reagent with a unique molecular structure that features a benzene ring substituted with a trifluoromethyl group and a pyridine ring with a methoxy group. 4-(6-Methoxypyridin-2-yl)benzotrifluoride is known for its potential applications in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries.

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  • 1202026-99-0 Structure

  • Basic information

    1. Product Name: 4-(6-Methoxypyridin-2-yl)benzotrifluoride
    2. Synonyms: 2-Methoxy-6-(4-(trifluoromethyl)phenyl)pyridine;4-(6-Methoxypyridin-2-yl)benzotrifluoride
    3. CAS NO:1202026-99-0
    4. Molecular Formula: C13H10F3NO
    5. Molecular Weight: 253.2198096
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1202026-99-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 283.0±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.232±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 2.00±0.25(Predicted)
    10. CAS DataBase Reference: 4-(6-Methoxypyridin-2-yl)benzotrifluoride(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-(6-Methoxypyridin-2-yl)benzotrifluoride(1202026-99-0)
    12. EPA Substance Registry System: 4-(6-Methoxypyridin-2-yl)benzotrifluoride(1202026-99-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1202026-99-0(Hazardous Substances Data)

1202026-99-0 Usage

Uses

Used in Pharmaceutical Industry:
4-(6-Methoxypyridin-2-yl)benzotrifluoride is used as a synthetic reagent for the preparation of substituted pyrazinone, pyrimidinone, and pyridone compounds. These compounds are of significant interest in the pharmaceutical industry due to their potential therapeutic properties and applications in the development of new drugs.
Used in Chemical Industry:
In the chemical industry, 4-(6-Methoxypyridin-2-yl)benzotrifluoride serves as an intermediate in the synthesis of various organic compounds, including those with potential applications in materials science, agrochemicals, and other specialized fields. Its unique structure and reactivity make it a valuable building block for the creation of novel molecules with specific properties and functions.

Check Digit Verification of cas no

The CAS Registry Mumber 1202026-99-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,2,0,2 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1202026-99:
(9*1)+(8*2)+(7*0)+(6*2)+(5*0)+(4*2)+(3*6)+(2*9)+(1*9)=90
90 % 10 = 0
So 1202026-99-0 is a valid CAS Registry Number.

1202026-99-0Relevant articles and documents

Potassium trimethylsilanolate enables rapid, homogeneous suzuki-miyaura cross-coupling of boronic esters

Delaney, Connor P.,Kassel, Vincent M.,Denmark, Scott E.

, p. 73 - 80 (2019/12/24)

Herein, a mild and operationally simple method for the Suzuki-Miyaura cross-coupling of boronic esters is described. Central to this advance is the use of the organic-soluble base, potassium trimethylsilanolate, which allows for a homogeneous, anhydrous cross-coupling. The coupling proceeds at a rapid rate, often furnishing products in quantitative yield in less than 5 min. By applying this method, a >10-fold decrease in reaction time was observed for three published reactions which required >48 h to reach satisfactory conversion.

Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes

Smith, Charlotte L.,Hirschh?user, Christoph,Malcolm, Georgia K.,Nasrallah, Daniel J.,Gallagher, Timothy

, p. 1904 - 1908 (2014/08/18)

Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.

Kumada-corriu cross-couplings with 2-pyridyl grignard reagents

Ackermann, Lutz,Potukuchi, Harish K.,Kapdi, Anant R.,Schulzke, Carola

supporting information; experimental part, p. 3300 - 3303 (2010/06/19)

Chemical Equation Presentation SPOs meet the challenge: A palladium complex derived from air- and moisture-stable secondary phosphine oxide (SPO) (1-Ad)2P(O)H enables general cross-coupling reactions of challenging electron-deficient 2-pyridyl Grignard reagents with ample scope (see scheme)

Palladium-catalyzed cross-coupling reactions of 2-pyridylborates with air-stable HASPO religands

Ackermann, Lutz,Potukuchi, Harish K.

experimental part, p. 2852 - 2856 (2010/03/26)

A novel, air-stable TADDOLP(O)H derivative bearing electron-withdrawing substituents allows for efficient Suzuki-Miyaura cross-couplings with challenging electron-deficient 2-pyr-idylborates as nucleophiles.

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