1202026-99-0

Basic information

• Product Name: 4-(6-Methoxypyridin-2-yl)benzotrifluoride
• Synonyms: 2-Methoxy-6-(4-(trifluoromethyl)phenyl)pyridine;4-(6-Methoxypyridin-2-yl)benzotrifluoride
• CAS NO: 1202026-99-0
• Molecular Formula: C₁₃H₁₀F₃NO
• Molecular Weight: 253.2198096
• Mol File: 1202026-99-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 283.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.232±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.00±0.25(Predicted)
• CAS DataBase Reference: 4-(6-Methoxypyridin-2-yl)benzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-Methoxypyridin-2-yl)benzotrifluoride(1202026-99-0)
• EPA Substance Registry System: 4-(6-Methoxypyridin-2-yl)benzotrifluoride(1202026-99-0)

Safety Data

• Hazardous Substances Data: 1202026-99-0(Hazardous Substances Data)

Usage

Uses

2-Methoxy-6-(4-(trifluoromethyl)phenyl)pyridine is a synthetic reagent used in the preparation of substituted pyrazinone, pyrimidinone and pyridone compounds.

Upstream product

• 455-13-0 4-Iodobenzotrifluoride 
• 1226769-58-9 (6-methoxy-2-pyridyl)magnesium bromide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 1034297-69-2 2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 164014-94-2 2-methoxy-6-(tri-n-butylstannyl)pyridine 

Downstream Products

• 1111110-54-3 6-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one 

Relevant articles and documents

Potassium trimethylsilanolate enables rapid, homogeneous suzuki-miyaura cross-coupling of boronic esters

Herein, a mild and operationally simple method for the Suzuki-Miyaura cross-coupling of boronic esters is described. Central to this advance is the use of the organic-soluble base, potassium trimethylsilanolate, which allows for a homogeneous, anhydrous cross-coupling. The coupling proceeds at a rapid rate, often furnishing products in quantitative yield in less than 5 min. By applying this method, a >10-fold decrease in reaction time was observed for three published reactions which required >48 h to reach satisfactory conversion.

Kumada-corriu cross-couplings with 2-pyridyl grignard reagents

Chemical Equation Presentation SPOs meet the challenge: A palladium complex derived from air- and moisture-stable secondary phosphine oxide (SPO) (1-Ad)2P(O)H enables general cross-coupling reactions of challenging electron-deficient 2-pyridyl Grignard reagents with ample scope (see scheme)