120205-57-4

Basic information

• Product Name: tert-Butyl (3S,4S,5S)-3-hydroxy-4--5-methylheptanoate
• Synonyms: tert-Butyl (3S,4S,5S)-3-hydroxy-4--5-methylheptanoate
• CAS NO: 120205-57-4
• Molecular Weight: 379.497
• Mol File: 120205-57-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-Butyl (3S,4S,5S)-3-hydroxy-4--5-methylheptanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (3S,4S,5S)-3-hydroxy-4--5-methylheptanoate(120205-57-4)
• EPA Substance Registry System: tert-Butyl (3S,4S,5S)-3-hydroxy-4--5-methylheptanoate(120205-57-4)

Safety Data

• Hazardous Substances Data: 120205-57-4(Hazardous Substances Data)

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 120205-56-3 N-Z-N-Me-(S,R)-isoleucinal 
• 501-53-1 benzyl chloroformate 
• 120205-56-3 benzyl methyl[(2S,3S)-3-methyl-1-oxopentan-2-yl]carbamate 
• 42417-66-3 (2S,3S)-3-methyl-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)pentanoic acid 
• 120205-55-2 benzyl [(2S,3S)-1-hydroxy-3-methylpentan-2-yl]methylcarbamate 
• 3160-59-6 N-Cbz-L-Isoleucine 
• 120205-55-2 N-Z-N-Me-(S,R)-isoleucinol 
• 163887-30-7 N-Z-N-Me-(S,R)-Ile 
• 319-78-8 isoleucine 
• 3160-59-6 N-benzyloxycarbonyl-isoleucine 

Downstream Products

• 120205-52-9 tert-butyl (3R,4S,5S)-4-[(2S)-2-[[(benzyloxy)carbonyl]amino]-N,3-dimethylbutanamido]-3-methoxy-5-methylheptanoate 
• 120205-53-0 (3R,4S,5S)-tert-butyl 4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoate 
• 120205-48-3 tert-Butyl (3R,4S,5S)-3-methoxy-4-(N-methylamino)-5-methylheptanoate hydrochloride 
• 110417-88-4 dolastatin 10 
• 154633-73-5 tert-Butyl (3S,4S,5S)-3-methoxy-4--5-methylheptanoate 

Relevant articles and documents

The dolastatins. 19. Synthesis of dolaisoleuine

The synthesis of dolaisoleuine as its tert-butyl ester (Dil-OBu(t)), a β- methoxy-γ-amino acid component of dolastatin 10, has been achieved employing as key step an aldol condensation between N-(benzyloxycarbonyl)-N-methyl- (S,S)-isoleucinal and tert-butyl acetate followed by O-methylation. The overall six-step reaction sequence to Dil proved to be convenient for routine preparation of this new amino acid and its stereochemical assignment as (3R,4S,5S)-N,O-dimethylisostatine.

Chiral Modifications of Dolastatin 10: The Potent Cytostatic Peptide (19aR)-Isodolastatin 10

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