154633-73-5

Basic information

• Product Name: tert-Butyl (3S,4S,5S)-3-methoxy-4--5-methylheptanoate
• Synonyms: tert-Butyl (3S,4S,5S)-3-methoxy-4--5-methylheptanoate
• CAS NO: 154633-73-5
• Molecular Weight: 393.524
• Mol File: 154633-73-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-Butyl (3S,4S,5S)-3-methoxy-4--5-methylheptanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (3S,4S,5S)-3-methoxy-4--5-methylheptanoate(154633-73-5)
• EPA Substance Registry System: tert-Butyl (3S,4S,5S)-3-methoxy-4--5-methylheptanoate(154633-73-5)

Safety Data

• Hazardous Substances Data: 154633-73-5(Hazardous Substances Data)

Upstream product

• 177769-64-1 (3S,4S,5S)-4--3-methoxy-5-methylheptanoic acid 
• 115-11-7 isobutene 
• 120205-56-3 benzyl methyl[(2S,3S)-3-methyl-1-oxopentan-2-yl]carbamate 
• 120205-55-2 benzyl [(2S,3S)-1-hydroxy-3-methylpentan-2-yl]methylcarbamate 
• 3160-59-6 N-Cbz-L-Isoleucine 
• 540-88-5 acetic acid tert-butyl ester 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 120205-57-4 tert-Butyl (3S,4S,5S)-3-hydroxy-4--5-methylheptanoate 
• 186581-53-3 diazomethane 

Downstream Products

• 120205-52-9 tert-butyl (3R,4S,5S)-4-[(2S)-2-[[(benzyloxy)carbonyl]amino]-N,3-dimethylbutanamido]-3-methoxy-5-methylheptanoate 
• 120205-53-0 (3R,4S,5S)-tert-butyl 4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoate 
• 110417-88-4 dolastatin 10 
• 173653-49-1 (3S,4S,5S)-4-[((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-methyl-amino]-3-methoxy-5-methyl-heptanoic acid tert-butyl ester 
• 130272-98-9 (S)-N-{(S)-1-[((1S,2S)-1-((S)-sec-Butyl)-2-methoxy-4-{(S)-2-[(1R,2R)-1-methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidin-1-yl}-4-oxo-butyl)-methyl-carbamoyl]-2-methyl-propyl}-2-dimethylamino-3-methyl-butyramide 
• 120205-48-3 tert-Butyl (3R,4S,5S)-3-methoxy-4-(N-methylamino)-5-methylheptanoate hydrochloride 

Relevant articles and documents

The dolastatins. 19. Synthesis of dolaisoleuine

The synthesis of dolaisoleuine as its tert-butyl ester (Dil-OBu(t)), a β- methoxy-γ-amino acid component of dolastatin 10, has been achieved employing as key step an aldol condensation between N-(benzyloxycarbonyl)-N-methyl- (S,S)-isoleucinal and tert-butyl acetate followed by O-methylation. The overall six-step reaction sequence to Dil proved to be convenient for routine preparation of this new amino acid and its stereochemical assignment as (3R,4S,5S)-N,O-dimethylisostatine.

The absolute configuration and synthesis of natural (-)-dolastatin 101

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