1202246-84-1

Upstream product

• 14660-52-7 ethyl 5-bromovalerate 
• 536-74-3 phenylacetylene 
• 89896-39-9 ethyl 5-azidovalerate 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 

Relevant academic research and scientific papers

Polymeric "clickase" Accelerates the Copper Click Reaction of Small Molecules, Proteins, and Cells

Recent work has shown that polymeric catalysts can mimic some of the remarkable features of metalloenzymes by binding substrates in proximity to a bound metal center. We report here an unexpected role for the polymer: multivalent, reversible, and adaptive

Copper(II) Acetylacetonate: An Efficient Catalyst for Huisgen-Click Reaction for Synthesis of 1,2,3-Triazoles in Water

An efficient and green copper(II) acetylacetonate-catalyzed protocol for the Huisgen-click reaction in water at 100 °C has been established. The protocol was not only suitable for the reaction between organic azides and alkynes, but also suitable for one-pot three-component reaction among alkyl halides, NaN3 and alkynes.

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "click" Reactions in Water and in Cells

We show that copper-containing metal-organic nanoparticles (MONPs) are readily synthesized via Cu(II)-mediated intramolecular cross-linking of aspartate-containing polyolefins in water. In situ reduction with sodium ascorbate yields Cu(I)-containing MONPs that serve as highly efficient supramolecular catalysts for alkyne-azide "click chemistry" reactions, yielding the desired 1,4-adducts at low parts per million catalyst levels. The nanoparticles have low toxicity and low metal loadings, making them convenient, green catalysts for alkyne-azide "click" reactions in water. The Cu-MONPs enter cells and perform efficient, biocompatible click chemistry, thus acting as intracellular nanoscale molecular synthesizers.

A layered double hydroxide, a synthetically useful heterogeneous catalyst for azide?alkyne cycloadditions in a continuous-flow reactor

A Cu(II)Fe(III)-layered double hydroxide is shown to efficiently catalyze 1,3-dipolar cycloadditions of organic azides to alkynes leading to valuable 1,2,3-triazoles. The benefits of continuous processing were exploited for reaction optimization and synth

Continuous-flow azide-alkyne cycloadditions with an effective bimetallic catalyst and a simple scavenger system

A flow chemistry-based technique is presented herein for Cu(i)-catalyzed azide-alkyne cycloadditions with a copper on iron bimetallic system as the catalyst and iron powder as a readily available copper scavenger. The method proved to be rapid and safe as

Copper on iron: Catalyst and scavenger for azide-alkyne cycloaddition

Dipolar cycloaddition of terminal alkynes and azides catalyzed by the Cu/Fe bimetallic system is reported. In the presence of a readily accessible nanosized copper source, the cycloaddition reaction can be easily achieved at ambient temperature with high

Highly active copper-catalysts for azide-alkyne cycloaddition

Bis-triphenylphosphano complexes of copper(i)-carboxylates serve as efficient catalysts for azide-alkyne cycloaddition. The triazole formation takes place straightforwardly at ambient temperature providing a wide variety of products with good yields in th

The sequential Sonogashira-click reaction: A versatile route to 4-aryl-1,2,3-triazoles

Aryl halides can be easily transformed in a one-pot procedure into 4-aryl-1,2,3-triazoles with palladium/copper-catalyzed Sonogashira-click reaction sequence, using trimethylsilylacetylene as acetylene surrogate.