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120226-28-0

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120226-28-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 120226-28-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,2,2 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 120226-28:
(8*1)+(7*2)+(6*0)+(5*2)+(4*2)+(3*6)+(2*2)+(1*8)=70
70 % 10 = 0
So 120226-28-0 is a valid CAS Registry Number.

120226-28-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(3R,5S)-3,5-dimethylmorpholin-4-yl]ethanone

1.2 Other means of identification

Product number -
Other names 1-((3S,5R)-3,5-Dimethyl-morpholin-4-yl)-ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120226-28-0 SDS

120226-28-0Relevant articles and documents

Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models

Lücking, Ulrich,Wortmann, Lars,Wengner, Antje M.,Lefranc, Julien,Lienau, Philip,Briem, Hans,Siemeister, Gerhard,B?mer, Ulf,Denner, Karsten,Sch?fer, Martina,Koppitz, Marcus,Eis, Knut,Bartels, Florian,Bader, Benjamin,Bone, Wilhelm,Moosmayer, Dieter,Holton, Simon J.,Ebersp?cher, Uwe,Grudzinska-Goebel, Joanna,Schatz, Christoph,Deeg, Gesa,Mumberg, Dominik,Von Nussbaum, Franz

, p. 7293 - 7325 (2020)

The ATR kinase plays a key role in the DNA damage response by activating essential signaling pathways of DNA damage repair, especially in response to replication stress. Because DNA damage and replication stress are major sources of genomic instability, selective ATR inhibition has been recognized as a promising new approach in cancer therapy. We now report the identification and preclinical evaluation of the novel, clinical ATR inhibitor BAY 1895344. Starting from quinoline 2 with weak ATR inhibitory activity, lead optimization efforts focusing on potency, selectivity, and oral bioavailability led to the discovery of the potent, highly selective, orally available ATR inhibitor BAY 1895344, which exhibited strong monotherapy efficacy in cancer xenograft models that carry certain DNA damage repair deficiencies. Moreover, combination treatment of BAY 1895344 with certain DNA damage inducing chemotherapy resulted in synergistic antitumor activity. BAY 1895344 is currently under clinical investigation in patients with advanced solid tumors and lymphomas (NCT03188965).

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