1202275-67-9

Upstream product

• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 91471-08-8 3-methoxy-4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 121-33-5 vanillin 

Downstream Products

• 1415219-32-7 1-(4,5-Dihydro-5-(4-hydroxy-3-methoxyphenyl)-3-(3,4, 5-trimethoxyphenyl)pyrazol-1-yl)ethanone 
• 1415219-26-9 1-(5-(4-((1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-3-methoxyphenyl)-4,5-dihydro-3-(3,4,5-trimethoxyphenyl)pyrazol-1-yl)ethanone 
• 1415219-57-6 1-(4,5-Dihydro-5-(3-methoxy-4-(prop-2-ynyloxy)phenyl)-3-(3,4,5-trimethoxyphenyl)pyrazol-1-yl)ethanone 
• 1357099-32-1 (E)-ethyl-2-(2-methoxy-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)phenoxy)acetate 
• 1357099-01-4 4β-[6-(2-methoxy-4-[(E)-3-(3,4,5-trimethoxyphenyl)-3-oxo-1-propenyl]phenoxy)hexanamido]-4-deoxypodophyllotoxin 
• 1357099-08-1 4β-[2-(2-methoxy-4-[(E)-3-(3,4,5-trimethoxyphenyl)-3-oxo-1-propenyl]phenoxy)acetamido]-4-deoxypodophyllotoxin 
• 1357099-39-8 (E)-2-(2-methoxy-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)phenoxy)acetic acid 
• 1224606-13-6 1-methyl-3-(3',4',5'-trimethoxyphenyl)-5-(4''-hydroxy-3''-methoxyphenyl)-4,5-dihydro-1H-pyrazole 

Relevant academic research and scientific papers

Syntheses of 2-methoxyestradiol and eugenol template based diarylpropenes as non-steroidal anticancer agents

Syntheses of 2-methoxyestradiol (1) and eugenol (6) template based conformationally flexible and rigid diarylpropenes, 14(a-l) and 20(a-e), as nonsteroidal anticancer agents have been performed. The synthesized compounds were evaluated for their anticance

Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors

Based on classical colchicine site ligands and a computational model of the colchicine binding site on beta tubulin, two classes of chalcone derivatives were designed, synthesized and evaluated for inhibition of tubulin assembly and toxicity in human canc

Synthesis of 1,2,3-triazole tethered bifunctional hybrids by click chemistry and their cytotoxic studies

In view of the drug resistance with most of the currently used anticancer drugs, molecular hybrids of pyrazolyl chalcones and p-nitro benzyl functionalities tethered by triazole ring have been synthesised and evaluated for cytotoxic studies against three human cancer cell lines (THP, COLO-205, A-549). The results of the preliminary investigation exhibited marked dependence of the cytotoxic activity on the electronic factors. Placement of naphthyl (JGPT-11) and trimethoxy phenyl ring (JGPT-6) as ring A proved to be extremely beneficial in enhancing the cytotoxic potential. Thus we herein report the synthesis and cytotoxic studies of a new class of molecular hybrids. Detailed investigation on the biological mechanistic insights of JGPT-11 and 6 is under progress.

Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents

A series of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxin congeners have been synthesized. All the twenty nine compounds were evaluated for anticancer activity against five human cancer cell lines (A-549, A375, MCF-7, HT-29 and ACHN). Some of the synthesized compounds showed good anticancer activity that is comparable to etoposide. The IC50 of compounds 17a and 17f is 2.7 and 2.1 μM respectively against A-549 cancer cell line. Flow cytometric analysis showed that these two compounds arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggested that 17a and 17f induced cell death by apoptosis.

The synthesis and Angiotensin Converting Enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives

A series of chalcones (1-9) and pyrazoles (10-18) was prepared to investigate their potential activity as Angiotensin I-Converting Enzyme (ACE) inhibitors. Their structures were verified by elemental analysis, UV, IR, MS, 1H NMR, 13C

Synthesis and biological evaluation of 3′,4′,5′-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation

A series of 23 3′,4′,5′-trimethoxychalcone analogues was synthesized and their inhibitory effects on nitric oxide (NO) production in LPS/IFN-γ-treated macrophages, and tumor cell proliferation has been investigated. 4-Hydroxy-3,3′,4′,5′-tetramethoxychalco