120230-46-8

Upstream product

• 120230-41-3 N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester 
• 1094673-91-2 N-(9-phenylfluorenyl)-3-methyl-L-aspartic acid α-tert-butyl β-methyl diester 

Downstream Products

• 120230-49-1 (2S,3R)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid tert-butyl ester 
• 120329-59-1 (2S,3R)-2-Benzyloxycarbonylamino-4-((S)-1-methoxycarbonyl-ethylamino)-3-methyl-butyric acid tert-butyl ester 
• 120328-49-6 (S)-2-((3S,4R)-3-Benzyloxycarbonylamino-4-methyl-2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester 
• 120230-58-2 (2S,3S)-2-Benzyloxycarbonylamino-3-methyl-4-oxo-butyric acid tert-butyl ester 
• 120230-56-0 (2S,3S)-tert-butyl 2-(benzyloxycarbonylamino)-4-hydroxy-3-methylbutanoate 
• 120230-48-0 tert-butyl (2S,3S)-2-<(9-phenylfluorenyl)amino>-3-methyl-4-oxobutanoate 

Relevant academic research and scientific papers

Native chemical ligation at valine: A contribution to peptide and glycopeptide synthesis

(Chemical Equation Presented) A Val-uable link: The title transformation is achieved by a two-step ligation, radicalbased desulfurization strategy (see scheme; NCL=native chemical ligation). After S→N acyl transfer, in which the acyl acceptor is a γ-thiol valine derivative, and site-specific dethiolation, a valine residue appears at the site of ligation. This method accomplishes ligations at Thr-Val and Pro-Val sites, and allows successful ligation of glycopeptide fragments.

Conformationally Constrained Peptides. Chirospecific Synthesis of 4-Alkyl-Substituted γ-Lactam-Bridged Dipeptides from L-Aspartic Acid

The synthesis of enantiomerically pure γ-lactam-bridged dipeptide analogues of Val-Ala, Ile-Ala, and β-MeLeu-Ala starting from L-aspartic acid is presented.N-(9-Phenylfluorenyl)-L-aspartic acid α-tert-butyl β-methyl diester and N-(9-Phenylfluorenyl)-L-asp