120230-47-9

Upstream product

• 1094673-91-2 N-(9-phenylfluorenyl)-3-methyl-L-aspartic acid α-tert-butyl β-methyl diester 
• 120230-41-3 N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester 
• 349148-54-5 (2S,3R)-2-Methyl-3-(9-phenyl-9H-fluoren-9-ylamino)-succinic acid 1-methyl ester 
• 55135-66-5 9-bromo-9-phenyl-9H-fluorene 
• 120230-43-5 (2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester 

Downstream Products

• 120262-55-7 tert-butyl (2S,3R)-2-<(benzoxycarbonyl)amino>-3-methyl-4-hydroxybutanoate 
• 120230-57-1 tert-butyl (2S,3R)-2-<(benzoxycarbonyl)amino>-3-methyl-4-oxobutanoate 
• 120230-60-6 (S)-2-((3S,4S)-3-Benzyloxycarbonylamino-4-methyl-2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester 
• 120230-59-3 (2S,3S)-2-Benzyloxycarbonylamino-4-((S)-1-methoxycarbonyl-ethylamino)-3-methyl-butyric acid tert-butyl ester 
• 120230-49-1 (2S,3S)-4-((S)-1-Methoxycarbonyl-ethylamino)-3-methyl-2-(9-phenyl-9H-fluoren-9-ylamino)-butyric acid tert-butyl ester 
• 120230-48-0 tert-butyl (2S,3R)-2-<(9-phenylfluorenyl)amino>-3-methyl-4-oxobutanoate 

Relevant academic research and scientific papers

Native chemical ligation at valine: A contribution to peptide and glycopeptide synthesis

(Chemical Equation Presented) A Val-uable link: The title transformation is achieved by a two-step ligation, radicalbased desulfurization strategy (see scheme; NCL=native chemical ligation). After S→N acyl transfer, in which the acyl acceptor is a γ-thiol valine derivative, and site-specific dethiolation, a valine residue appears at the site of ligation. This method accomplishes ligations at Thr-Val and Pro-Val sites, and allows successful ligation of glycopeptide fragments.

Synthesis of optically active 2-alkyl-3,4-iminobutanoic acids. β-amino acids containing an aziridine heterocycle

All four stereoisomers of 2-alkyl-3,4-iminobutanic acid, a novel class of β-amino acids bearing a chemically versatile aziridine ring, were synthesized starting with aspartic acid. The synthetic strategy involves the introduction of an alkyl group at the β-position of fully protected optically active aspartic acid followed by the construction of an aziridine ring making use of the α-carboxylate and α-amino groups. The α-carboxylate was reduced to the corresponding alcohol, which was then subjected to cyclization to form an aziridine ring with the N-protected amino group. Removal of the protection groups yielded the target compounds.

Conformationally Constrained Peptides. Chirospecific Synthesis of 4-Alkyl-Substituted γ-Lactam-Bridged Dipeptides from L-Aspartic Acid

The synthesis of enantiomerically pure γ-lactam-bridged dipeptide analogues of Val-Ala, Ile-Ala, and β-MeLeu-Ala starting from L-aspartic acid is presented.N-(9-Phenylfluorenyl)-L-aspartic acid α-tert-butyl β-methyl diester and N-(9-Phenylfluorenyl)-L-asp