1202497-85-5

Basic information

• Product Name: 1-([5'-([(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl)-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl]methyl)cyclohexanecarbonitrile
• Synonyms: 1-([5'-([(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl)-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl]methyl)cyclohexanecarbonitrile
• CAS NO: 1202497-85-5
• Molecular Weight: 503.62
• Mol File: 1202497-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-([5'-([(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl)-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl]methyl)cyclohexanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-([5'-([(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl)-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl]methyl)cyclohexanecarbonitrile(1202497-85-5)
• EPA Substance Registry System: 1-([5'-([(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl)-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl]methyl)cyclohexanecarbonitrile(1202497-85-5)

Safety Data

• Hazardous Substances Data: 1202497-85-5(Hazardous Substances Data)

Upstream product

• 869223-90-5 5'-([(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl)spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one 
• 112905-95-0 1-(chloromethyl)cyclohexanecarbonitrile 

Relevant articles and documents

3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3

Cysteine-dependant aspartyl protease (caspase) activation has been implicated as a part of the signal transduction pathway leading to apoptosis. It has been postulated that caspase-3 inhibition could attenuate cell damage after an ischemic event and thereby providing for a novel neuroprotective treatment for stroke. As part of a program to develop a small molecule inhibitor of caspase-3, a novel series of 3,4-dihydropyrimido(1,2-a)indol-10(2H)-ones (pyrimidoindolones) was identified. The synthesis, biological evaluation and structure-activity relationships of the pyrimidoindolones are described.