1202577-74-9

Basic information

• Product Name: methyl (3S)-3-(4-benzyloxyphenyl)-3-hydroxy propionate
• Synonyms: methyl (3S)-3-(4-benzyloxyphenyl)-3-hydroxy propionate
• CAS NO: 1202577-74-9
• Molecular Weight: 286.328
• Mol File: 1202577-74-9.mol

Chemical Properties

• CAS DataBase Reference: methyl (3S)-3-(4-benzyloxyphenyl)-3-hydroxy propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (3S)-3-(4-benzyloxyphenyl)-3-hydroxy propionate(1202577-74-9)
• EPA Substance Registry System: methyl (3S)-3-(4-benzyloxyphenyl)-3-hydroxy propionate(1202577-74-9)

Safety Data

• Hazardous Substances Data: 1202577-74-9(Hazardous Substances Data)

Upstream product

• 705939-73-7 methyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate 

Downstream Products

• 1202576-65-5 (3S)-3-(4-{[(1R)-4-cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid 
• 1202575-65-2 (3S)-3-ethoxy-3-(4-{[4-(trifluoromethyl)benzyl]oxy}phenyl)propanoic acid 
• 1202577-77-2 (3S)-3-(4-benzyloxyphenyl)-3-ethoxypropyloxy triisopropylsilane 
• 1202576-63-3 (3S)-3-(4-{[(1R)-4,6-dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid 
• 1202576-60-0 (3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid 
• 1202576-59-7 (3S)-3-ethoxy-3-(4-{[(1R)-4-methyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propanoic acid 
• 1202576-58-6 (3S)-3-ethoxy-3-(4-{[(1R)-4-ethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propanoic acid 
• 1202576-56-4 (3S)-3-ethoxy-3-(4-{[(1R)-5-fluoro-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propionic acid 
• 1202575-67-4 (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-propanoic acid 
• 1202575-66-3 (3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid 
• 1202578-24-2 (3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol 
• 1202578-18-4 (3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol 
• 1202578-17-3 {[(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropyl]oxy}(triisopropyl)silane 
• 1202578-07-1 (3S)-3-(4-{[(1R)-4-(Difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol 

Relevant articles and documents

Discovery of DS-1558: A potent and orally bioavailable GPR40 agonist

GPR40 is a G protein-coupled receptor that is predominantly expressed in pancreatic β-cells. GPR40 agonists stimulate insulin secretion in the presence of high glucose concentration. On the basis of this mechanism, GPR40 agonists are possible novel insuli

Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558

GPR40 agonists stimulate insulin secretion only under the presence of high glucose concentration. Based on this mechanism, GPR40 agonists are believed to be promising novel insulin secretagogues with low risk of hypoglycemia. The optimizations of 3-aryl-3-ethoxypropanoic acids were performed to improve in vitro activity. We discovered compound 29r (DS-1558), (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propanoic acid, which was confirmed to have an enhancing effect on glucose-dependent insulin secretion after intravenous glucose injection in SD rats.

CARBOXYLIC ACID COMPOUND

To find a therapeutic agent and/or a preventive agent for diabetes mellitus or the like having excellent activity and safety. A compound represented by the following general formula (I), or a pharmacologically acceptable salt thereof. In the formula, X re