1202575-67-4 Usage
Uses
Used in Organic Synthesis:
(3S)-3-ethoxy-3-(4-[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxyphenyl)-propanoic acid is used as a building block in organic synthesis for [application reason]. Its complex structure allows for the creation of various derivatives with potential applications in different industries.
Used in Chemical Research:
In the field of chemical research, (3S)-3-ethoxy-3-(4-[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxyphenyl)-propanoic acid is used as a research tool for [application reason]. Its unique properties and reactivity make it valuable for studying various chemical reactions and mechanisms.
Used in Pharmaceutical Research:
(3S)-3-ethoxy-3-(4-[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxyphenyl)-propanoic acid is used as a research compound in pharmaceutical research for [application reason]. Its potential as a precursor to pharmaceutically active molecules or as a probe for biological targets is being explored.
Used in the Pharmaceutical Industry:
In the pharmaceutical industry, (3S)-3-ethoxy-3-(4-[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxyphenyl)-propanoic acid is used as a starting material for the development of new drugs for [application reason]. Its structural diversity and potential for modification make it a promising candidate for drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1202575-67-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,2,5,7 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1202575-67:
(9*1)+(8*2)+(7*0)+(6*2)+(5*5)+(4*7)+(3*5)+(2*6)+(1*7)=124
124 % 10 = 4
So 1202575-67-4 is a valid CAS Registry Number.
1202575-67-4Relevant articles and documents
Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558
Takano, Rieko,Yoshida, Masao,Inoue, Masahiro,Honda, Takeshi,Nakashima, Ryutaro,Matsumoto, Koji,Yano, Tatsuya,Ogata, Tsuneaki,Watanabe, Nobuaki,Hirouchi, Masakazu,Kimura, Takako,Toda, Narihiro
, p. 5546 - 5565 (2015/11/11)
GPR40 agonists stimulate insulin secretion only under the presence of high glucose concentration. Based on this mechanism, GPR40 agonists are believed to be promising novel insulin secretagogues with low risk of hypoglycemia. The optimizations of 3-aryl-3-ethoxypropanoic acids were performed to improve in vitro activity. We discovered compound 29r (DS-1558), (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propanoic acid, which was confirmed to have an enhancing effect on glucose-dependent insulin secretion after intravenous glucose injection in SD rats.
Discovery of DS-1558: A potent and orally bioavailable GPR40 agonist
Takano, Rieko,Yoshida, Masao,Inoue, Masahiro,Honda, Takeshi,Nakashima, Ryutaro,Matsumoto, Koji,Yano, Tatsuya,Ogata, Tsuneaki,Watanabe, Nobuaki,Hirouchi, Masakazu,Yoneyama, Tomoko,Ito, Shuichiro,Toda, Narihiro
, p. 266 - 270 (2015/03/30)
GPR40 is a G protein-coupled receptor that is predominantly expressed in pancreatic β-cells. GPR40 agonists stimulate insulin secretion in the presence of high glucose concentration. On the basis of this mechanism, GPR40 agonists are possible novel insuli
CARBOXYLIC ACID COMPOUND
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, (2011/04/14)
To find a therapeutic agent and/or a preventive agent for diabetes mellitus or the like having excellent activity and safety. A compound represented by the following general formula (I), or a pharmacologically acceptable salt thereof. In the formula, X re
