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4-Bromo-2-ethylthiazole is an organic compound that features a thiazole ring with a bromine atom at the 4-position and an ethyl group at the 2-position. This chemical structure endows it with unique properties that make it a valuable intermediate in the synthesis of various pharmaceuticals and organic compounds.

120258-27-7

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120258-27-7 Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-ethylthiazole is used as a key intermediate in the synthesis of epothilone E analogs, which are important microtubule-stabilizing agents with potential applications in cancer therapy. The Stille coupling reaction, a type of cross-coupling reaction in organic chemistry, is employed to incorporate 4-Bromo-2-ethylthiazole into the target molecule, facilitating the development of new and effective anticancer drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 120258-27-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,2,5 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 120258-27:
(8*1)+(7*2)+(6*0)+(5*2)+(4*5)+(3*8)+(2*2)+(1*7)=87
87 % 10 = 7
So 120258-27-7 is a valid CAS Registry Number.

120258-27-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-ethyl-4-bromothiazole

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:120258-27-7 SDS

120258-27-7Upstream product

120258-27-7Downstream Products

120258-27-7Relevant academic research and scientific papers

Epothilone analogs

-

, (2008/06/13)

Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.

Total synthesis of Epothilone E and related side-chain modified analogues via a stille coupling based strategy

Nicolaou,King,Finlay,He,Roschangar,Vourloumis,Vallberg,Sarabia,Ninkovic,Hepworth

, p. 665 - 697 (2007/10/03)

A Stille coupling strategy has been utilized to complete a total synthesis of epothilone E from vinyl iodide 7 and thiazole-stannane 8h. The central core fragment 7 and its trans-isomer 11 were prepared from triene 15 using ring-closing metathesis (RCM),

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