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1202580-59-3

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1202580-59-3 Usage

General Description

1H-1,2,3-Triazole-1-octanamide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)- is a chemical compound that consists of a triazole ring, an octanamide group, and a biphenyl-2-yl substituent linked to a 3-pyridinyl group. It is a heterocyclic compound with potential medicinal and biological properties, and it can be used in various research and pharmaceutical applications. The specific chemical structure and functional groups present in this compound make it suitable for further investigation and potential use in drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 1202580-59-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,2,5,8 and 0 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1202580-59:
(9*1)+(8*2)+(7*0)+(6*2)+(5*5)+(4*8)+(3*0)+(2*5)+(1*9)=113
113 % 10 = 3
So 1202580-59-3 is a valid CAS Registry Number.

1202580-59-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1202580-59-3 SDS

1202580-59-3Downstream Products

1202580-59-3Relevant articles and documents

Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities

Bai, Jinhong,Liao, Chenzhong,Liu, Yanghan,Qin, Xiaochu,Chen, Jiaxuan,Qiu, Yatao,Qin, Dongguang,Li, Zheng,Tu, Zheng-Chao,Jiang, Sheng

, p. 5766 - 5779 (2016/07/06)

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) has the potential to directly limit NAD production in cancer cells and is an effective strategy for cancer treatment. Using a structure-based strategy, we have designed a new class of potent small-molecule inhibitors of NAMPT. Several designed compounds showed promising antiproliferative activities in vitro. (E)-N-(5-((4-(((2-(1H-Indol-3-yl)ethyl)(isopropyl)amino)methyl)phenyl)amino)pentyl)-3-(pyridin-3-yl)acrylamide, 30, bearing an indole moiety, has an IC50 of 25.3 nM for binding to the NAMPT protein and demonstrated promising inhibitory activities in the nanomolar range against several cancer cell lines (MCF-7 GI50 = 0.13 nM; MDA-MB-231 GI50 = 0.15 nM). Triple-negative breast cancer is the most malignant subtype of breast cancer with no effective targeted treatments currently available. Significant antitumor efficacy of compound 30 was achieved (TGI was 73.8%) in an orthotopic MDA-MB-231 triple-negative breast cancer xenograft tumor model. This paper reports promising lead molecules for the inhibition of NAMPT which could serve as a basis for further investigation.

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