120273-85-0Relevant academic research and scientific papers
Photochemical Preparation of 1,2-Dihydro-3 H-indazol-3-ones in Aqueous Solvent at Room Temperature
Zhu, Jie S.,Kraemer, Niklas,Li, Clarabella J.,Haddadin, Makhluf J.,Kurth, Mark J.
, p. 15493 - 15498 (2018)
o-Nitrosobenzaldehyde is a reactive intermediate useful in the synthesis of nitrogen heterocycles. Previous strategies for using o-nitrosobenzaldehyde involve its isolation via chromatography and/or formation under harsh conditions. Herein, this intermedi
A B2(OH)4-Mediated Synthesis of 2-Substituted Indazolone and Its Application in a DNA-Encoded Library
Bao, Yapeng,Deng, Zongfa,Feng, Jing,Zhu, Weiwei,Li, Jin,Wan, Jinqiao,Liu, Guansai
supporting information, p. 6277 - 6282 (2020/08/24)
Indazolone cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. In this report, a mild and efficient approach to 2-substituted indazolones via B2(OH)4-mediated reductive N-N b
Photocatalyst-free Synthesis of Indazolones under CO2 Atmosphere
Yang, Tianbao,Lu, Huiai,Qiu, Renhua,Hong, Ling,Yin, Shuang-Feng,Kambe, Nobuaki
supporting information, p. 1436 - 1442 (2019/03/26)
A convenient photocatalyst-free method for the synthesis of redox-active 1,2-dihydro-3H-indazol-3-one derivatives from (2-nitroaryl)methanol and amines was developed. The reaction proceeded efficiently at room temperature by irradiation of UV light under CO2 atmosphere (1.0 atm, flow) without any photocatalysts or additives. This mild, operationally simple method shows wide functional tolerance. The carbamate formed in situ from CO2 and amine is proposed to be the key of this reaction. Some of these compounds synthesized by the present method were found to exhibit high anticancer activities, which can lower the viability of cancerous cell lines such as HeLa, MCF-7 and U87.
Preparation method for synthesizing indazolinone compound by carbon dioxide promotion and photocatalyst-free photo-induction
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Paragraph 0055-0056, (2019/05/22)
The invention discloses a preparation method for synthesizing an indazolinone compound by carbon dioxide promotion and photocatalyst-free photo-induction. A quinoline 2-nitrobenzyl alcohol compound and an amine derivative serve as raw materials, low-priced and easily available common bulbs serve as reaction light sources, carbon dioxide serves as a promoter, common organic solvents serve as reaction solvents, reaction is performed at a certain temperature for a certain time, the indazolinone compound can be prepared in a high-yield and high-selectivity manner, and high yield is obtained in gram-scale amplification reaction.
N-N Bond Formation between Primary Amines and Nitrosos: Direct Synthesis of 2-Substituted Indazolones with Mechanistic Insights
Zhu, Jie S.,Kraemer, Niklas,Shatskikh, Marina E.,Li, Clarabella J.,Son, Jung-Ho,Haddadin, Makhluf J.,Tantillo, Dean J.,Kurth, Mark J.
supporting information, p. 4736 - 4739 (2018/08/24)
A concise, one-step route to indazolones from primary alkyl amines and o-nitrobenzyl alcohols is reported. The key step in this readily scalable indazolone forming process involves base-mediated in situ o-nitrobenzyl alcohol → o-nitrosobenzaldehyde conversion. Although this functional group interconversion is known to be useful for 2H-indazole synthesis, its reactivity was modulated for indazolone formation.
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity
Bruneau,Delvare,Edwards,McMillan
, p. 1028 - 1036 (2007/10/02)
Since the hypothetical mechanisms of hydroperoxydation of arachidonic acid by, respectively, 5-lipoxygenase (5-LPO) and cyclooxygenase (CO) involve a redox cycle, a compound which reduces 5-LPO and CO to their inactive state would give a nonselective inhi
