1202747-69-0Relevant articles and documents
A practical synthesis of cephalostatin 1
Shi, Yong,Jia, Lanqi,Xiao, Qing,Lan, Quan,Tang, Xiaohu,Wang, Dahai,Li, Min,Ji, Yu,Zhou, Tao,Tian, Weisheng
, p. 786 - 790 (2011/10/09)
Let's get practical: A new practical synthetic strategy for natural sterols starting from pregnan-(16S,20S)-diols and steroid-(16S),22-lactones is presented. A tandem double oxymercuration-demercuration and a substitution-ketalization cascade are consider
Enantioselective synthesis of (+)-cephalostatin 1
Fortner, Kevin C.,Kato, Darryl,Tanaka, Yoshiki,Shair, Matthew D.
supporting information; experimental part, p. 275 - 280 (2010/03/25)
This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C-H hydroxylation of a sterol at C12, Au(I)-catalyzed 5-endo-dig cyclization, and a kinetic spiroketalization.