120285-03-2

Upstream product

• 109-01-3 1-methyl-piperazine 
• 120285-00-9 3,4-Dichloro-1-phenylisoquinoline 
• 17507-05-0 1-phenyl-1,4-dihydro-3(2H)-isoquinolinone 
• 72179-14-7 3-Chloro-4-dimethylaminomethylene-1,4-dihydroisoquinoline 

Downstream Products

• 72736-10-8 3-(4-methyl-piperazin-1-yl)-1-phenyl-isoquinoline 

Relevant academic research and scientific papers

Synthesis and Reactions of Isoquinoline Derivatives III. Synthesis and Reactions of 3,4-Dihalogeno-1-phenylisoquinolines

Reaction of 1-phenyl-1,4-dihydro-3(2H)isoquinolinone (1) with phosphorus pentahalides as well as a two-step procedure involving a Vilsmeier-Haack acylation of 1 followed by oxidative cleavage with sodium hypohalites make 3,4-dihalogeno-1-phenylisoquinolines easily available.