72736-10-8

Upstream product

• 72118-88-8 3-Chloro-1-phenyl-isoquinoline-4-carboxylic acid 
• 72179-14-7 3-Chloro-4-dimethylaminomethylene-1,4-dihydroisoquinoline 
• 120285-00-9 3,4-Dichloro-1-phenylisoquinoline 
• 17507-05-0 1-phenyl-1,4-dihydro-3(2H)-isoquinolinone 
• 109-01-3 1-methyl-piperazine 
• 120285-03-2 4-Chloro-3-(4-methylpiperazino)-1-phenylisoquinoline 

Relevant academic research and scientific papers

Synthesis and Reactions of Isoquinoline Derivatives III. Synthesis and Reactions of 3,4-Dihalogeno-1-phenylisoquinolines

Reaction of 1-phenyl-1,4-dihydro-3(2H)isoquinolinone (1) with phosphorus pentahalides as well as a two-step procedure involving a Vilsmeier-Haack acylation of 1 followed by oxidative cleavage with sodium hypohalites make 3,4-dihalogeno-1-phenylisoquinolines easily available.

3-Piperidino or apiperazino-1-phenyl or 1-substituted phenyl isoquinoline and antidepressant compositions thereof

Isoquinolines of the formula STR1 in which R1 is piperidino, piperazino or piperazino N-substituted thereof by alkyl of 1 to 4 carbon atoms, alkylene of 1 to 4 carbon atoms wherein said alkylene is substituted in turn by fluorobenzoyl, or CHO;