1202889-65-3

Usage

Structure

A benzene ring with a bromine atom at position 2 and a chlorine atom at position 4, and an ethylamine group attached to the 2nd carbon atom.

Classification

Amine compound

Applications

Organic synthesis, pharmaceutical chemistry, building block for the synthesis of various pharmaceuticals and bioactive compounds.

Potential

Biological activities, valuable intermediate in organic and medicinal chemistry research, development of new drugs and pharmaceuticals.

Upstream product

• 869319-28-8 (E)-2-bromo-4-chloro-1-(2-nitrovinyl)benzene 
• 156-41-2 4-chlorophenylethylamine 
• 1202889-66-4 2-bromo-4-chloro-1-(dibromomethyl)benzene 
• 27139-97-5 2-bromo-4-chloro-1-methyl-benzene 
• 84459-33-6 2-bromo-4-chlorobenzaldehyde 
• 1202889-67-5 2-bromo-4-chloro-1-[2-nitroethenyl]benzene 

Downstream Products

• 1273546-89-6 tert-butyl [2-(2-bromo-4-chlorophenyl)ethyl]carbamate 
• 846589-98-8 Lorcaserin hydrochloride 

Relevant academic research and scientific papers

PYRROLO[2,3-B]PYRIDINES AS HPK1 INHIBITOR AND USES THEREOF

Disclosed herein is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

FACTOR XIA-INHIBITING PYRIDOBENZAZEPINE AND PYRIDOBENZAZOCINE DERIVATIVES

The invention relates to substituted pyridobenzazepine and pyridobenzazocine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Synthesis method of lorcaserin

Belonging to the field of pharmaceutical chemistry, the invention discloses a synthesis method of lorcaserin. The method includes: taking 4-chlorophenethylamine as the raw material, carrying out reductive amination reaction with acrolein to prepare N-allyl-4-chloro-phenethylamine (compound 2), protecting the amino of compound2 by with t-butyloxycarboryl (Boc) to obtain N-Boc-N-allyl-4-chloro-phenethylamine (compound 3), subjecting the compound 3 to palladium acetate catalyzed cyclization to obtain a compound 4, conducting catalytic hydrogenation on the compound 4 to obtain N-Boc-lorcaserin, removing the Boc group under an acidic condition to obtain a lorcaserin crude product, and performing further purification to obtain lorcaserin. The synthesis method provided by the invention has the advantages of cheap and easily available reagent, safe and reliable reaction, recyclable reaction solvent, simple post-treatment operation, and environment-friendliness, and is conducive to large-scale industrial production.

6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES

Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.