120347-93-5Relevant academic research and scientific papers
Base-promoted cascade C-C coupling/N-α-sp3C-H hydroxylation for the regiospecific synthesis of 3-hydroxyisoindolinones
Shen, Jinhai,You, Qihua,Fu, Qi,Kuai, Changsheng,Huang, Huabin,Zhao, Li,Zhuang, Zhixia
, p. 5170 - 5173 (2017)
A base-promoted cascade reaction for the regiospecific synthesis of substituted 3-hydroxyisoindolinones under transition-metal-free conditions is developed. The base-mediated C-C bond coupling and N-α-sp3C-H bond hydroxylation are involved in t
3-hydroxy isoindole-1-ketone derivative and preparation method thereof
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Paragraph 0067; 0068; 0069; 0070, (2017/11/04)
The invention discloses a preparation method of a 3-hydroxy isoindole-1-ketone derivative (formula 2). A compound as shown by formula (1) is used for carrying out substitution reaction in a solvent in the presence of alkali and air to obtain the 3-hydroxy
Regioselective Formation of Hydroxy Lactams from Pyridine-2,3-dicarboximides and their Cyclodehydration to Pyridopyrrolo-fused Heterocyclic Systems
Hitchings, Gregory J.,Vernon, John M.
, p. 1757 - 1763 (2007/10/02)
Grignard reactions of pyridine-2,3-dicarboximides involve attack at the carbonyl group closer to the pyridine nitrogen atom to give 7-hydroxypyrrolopyridin-5(7H)-one derivatives.Reduction of the same imides with sodium borohydride gives mixtures of regiosomeric hydroxy lactams, in which the 7-hydroxypyrrolopyridin-5-ones are the major components.Hydroxy lactams derived by either of these two methods from pyridine-2,3-dicarboximides containing N-benzyl, N-2-phenylethyl, N-2-(indol-3-yl)ethyl, or N-biphenyl-2-yl substituents are cyclised by heating in trifluoroacetic or polyphosphoric acid to give derivatives of new pyridopyrrolo-fused heterocyclic systems.
New fused heterocyclic systems derived from pyridine-2,3-dicarboximides
Hitchings, Gregory J.,Vernon, John M.
, p. 623 - 624 (2007/10/02)
α-Hydroxylactams (8), formed by regioselective reduction or Grignard addition to pyridine-2,3-dicarboximides (7), undergo acid-catalysed cyclodehydration to give the new pyrido[2′,3′: 3,4]-pyrrolo fused heterocyclic systems (10)-(13).
