120347-97-9Relevant academic research and scientific papers
Potassium Hydroxide-Catalyzed Chemoselective Reduction of Cyclic Imides with Hydrosilanes: Synthesis of ω-Hydroxylactams and Lactams
Ding, Guangni,Li, Chengjun,Shen, Yifan,Lu, Bin,Zhang, Zhaoguo,Xie, Xiaomin
, p. 1241 - 1250 (2016/04/26)
Potassium hydroxide-catalyzed hydrosilylation exhibits excellent activity and chemoselectivity for the reduction of cyclic imides under mild reaction conditions. The chemoselectivity of the reduction system may be readily tuned by changing the identity an
Novel synthesis of aza-phthalimidine hydroxylactams
Fan, Bolin,Liu, Zenglu,Tang, Mei,Xu, Yun,Tang, Xiaowei,Mao, Zhenmin
, p. 3231 - 3242 (2008/12/23)
A novel and convenient synthetic route for preparing aza-phthalimidine hydroxylactams (5a-j) by N-bromosuccinimide (NBS) was developed. This method involved the substitution reactions of substrates (3a-j) with NBS via unstable intermediate bromides (4a-j) rapidly hydrolyzed into hydroxyl products in the course of the workup process. Copyright Taylor & Francis Group, LLC.
Regioselective Formation of Hydroxy Lactams from Pyridine-2,3-dicarboximides and their Cyclodehydration to Pyridopyrrolo-fused Heterocyclic Systems
Hitchings, Gregory J.,Vernon, John M.
, p. 1757 - 1763 (2007/10/02)
Grignard reactions of pyridine-2,3-dicarboximides involve attack at the carbonyl group closer to the pyridine nitrogen atom to give 7-hydroxypyrrolopyridin-5(7H)-one derivatives.Reduction of the same imides with sodium borohydride gives mixtures of regiosomeric hydroxy lactams, in which the 7-hydroxypyrrolopyridin-5-ones are the major components.Hydroxy lactams derived by either of these two methods from pyridine-2,3-dicarboximides containing N-benzyl, N-2-phenylethyl, N-2-(indol-3-yl)ethyl, or N-biphenyl-2-yl substituents are cyclised by heating in trifluoroacetic or polyphosphoric acid to give derivatives of new pyridopyrrolo-fused heterocyclic systems.
Magnesium Ion Assisted Highly Regio- and Chemoselective Reduction of 5H-Pyrrolopyridine-5,7(6H)-diones with Sodium Borohydride. A Convenient Synthesis of 6,7-Dihydro-7-hydroxy-5H-pyrrolopyridin-5-ones
Goto, Takehiko,Konno, Michio,Saito, Minoru,Sato, Ryu
, p. 1205 - 1210 (2007/10/02)
6-Substituted and unsubstituted 6,7-dihydro-7-hydroxy-5H-pyrrolopyridin-5-ones were predominantly obtained in excellent yield by the reduction of the corresponding 5,7-diones with sodium borohydride in the presence of Mg ion at 0 deg C.The highly r
New fused heterocyclic systems derived from pyridine-2,3-dicarboximides
Hitchings, Gregory J.,Vernon, John M.
, p. 623 - 624 (2007/10/02)
α-Hydroxylactams (8), formed by regioselective reduction or Grignard addition to pyridine-2,3-dicarboximides (7), undergo acid-catalysed cyclodehydration to give the new pyrido[2′,3′: 3,4]-pyrrolo fused heterocyclic systems (10)-(13).
