1203506-48-2Relevant articles and documents
Diversity-oriented synthesis of quinolines via Friedlaender annulation reaction under mild catalytic conditions
Subhas Bose,Idrees, Mohd,Jakka,Venkateswara Rao
experimental part, p. 100 - 110 (2010/10/19)
An efficient and practical method has been manifested for the diversity-oriented synthesis of quinolines via Friedlaender annulation reaction for the generation of a wide range of structurally interesting and pharmacologically significant compounds by using eerie ammonium, nitrate as a catalyst (10 mol %) at ambient temperature in 45 min, A variety of functional groups are introduced at various positions of the quinoline moiety, and further the diversity of the core skeleton was expanded at R1 and R 2 positions by the synthesis of various hybrids. Initial screening of the compounds for cytotoxicity against a series of cancer cell lines showed promising results.
