120355-29-5Relevant academic research and scientific papers
Synthesis and in vitro characterization of a tissue-selective fullerene: vectoring C(60)(OH)(16)AMBP to mineralized bone.
Gonzalez, Kelly A,Wilson, Lon J,Wu, Wenju,Nancollas, George H
, p. 1991 - 1997 (2002)
A tissue-vectored bisphosphonate fullerene, C(60)(OH)(16)AMBP [4,4-bisphosphono-2-(polyhydroxyl-1,2-dihydro-1,2-methanofullerene[60]-61-carboxamido)butyric acid], designed to target bone tissue has been synthesized and evaluated in vitro. An amide bisphosphonate addend, in conjunction with multiple hydroxyl groups, confers a strong affinity for the calcium phosphate mineral hydroxyapatite of bone. Constant composition crystal growth studies indicate that C(60)(OH)(16)AMBP reduces hydroxyapatite mineralization by 50% at a concentration of 1 microM, following a non-Langmuirian mechanism. Parallel studies with C(60)(OH)(30) also indicate an affinity for hydroxyapatite, but at a reduced level (28% crystal growth rate reduction at 1 microM) compared with C(60)(OH)(16)AMBP. This study is the first to demonstrate that a fullerene-based material can be successfully targeted to a selected tissue as a step toward the development of such materials for medical purposes, in general.
Synthesis of novel functionalized gem-bisphosphonates
Sturtz,Guervenou
, p. 661 - 662 (2007/10/02)
Michael-type addition of carbanions to tetraethyl ethylidenebisphosphonate affords functionalized gem-bisphosphonates, which are potentially useful in the therapy of bone tissues.
