1203663-14-2

Basic information

• Product Name: 4-(4-bromo-2-fluorophenylamino)-1H-indazole-5-carboxylic acid (2-vinyloxyethoxy)amide
• Synonyms: 4-(4-bromo-2-fluorophenylamino)-1H-indazole-5-carboxylic acid (2-vinyloxyethoxy)amide
• CAS NO: 1203663-14-2
• Molecular Weight: 435.252
• Mol File: 1203663-14-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-bromo-2-fluorophenylamino)-1H-indazole-5-carboxylic acid (2-vinyloxyethoxy)amide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromo-2-fluorophenylamino)-1H-indazole-5-carboxylic acid (2-vinyloxyethoxy)amide(1203663-14-2)
• EPA Substance Registry System: 4-(4-bromo-2-fluorophenylamino)-1H-indazole-5-carboxylic acid (2-vinyloxyethoxy)amide(1203663-14-2)

Safety Data

• Hazardous Substances Data: 1203663-14-2(Hazardous Substances Data)

Upstream product

• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 1203662-32-1 4-bromo-indazole-1,5-dicarboxylic acid di-tert-butyl ester 
• 1203662-37-6 4-bromo-1H-indazole-5-carboxylic acid tert-butyl ester 
• 1203662-69-4 4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-1,5-dicarboxylic acid di-tert-butylester 
• 1203662-35-4 2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester 
• 951884-50-7 2-bromo-4-fluorobenzoic acid tert-butyl ester 
• 391212-29-6 O-(2-vinyloxyethyl)hydroxylamine 
• 1203662-65-0 4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-5-carboxylic acid 

Downstream Products

• 1203663-13-1 4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-5-carboxylic acid (2-hydroxyethoxy)amide 

Relevant articles and documents

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions

Using structure-based design, two novel series of highly potent biaryl amine mitogen-activated protein kinase kinase (MEK) inhibitors have been discovered. These series contain an H-bond acceptor, in a shifted position compared with previously disclosed compounds, and an adjacent H-bond donor, resulting in a bidentate interaction with the Ser212 residue of MEK1. The most potent compound identified, 1 (G-894), is orally active in in vivo pharmacodynamic and tumor xenograft models.