1203719-13-4

Basic information

• Product Name: 1-(2,6-difluorobenzyl)-4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine
• Synonyms: 1-(2,6-difluorobenzyl)-4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine
• CAS NO: 1203719-13-4
• Molecular Weight: 391.771
• Mol File: 1203719-13-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,6-difluorobenzyl)-4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-difluorobenzyl)-4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine(1203719-13-4)
• EPA Substance Registry System: 1-(2,6-difluorobenzyl)-4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine(1203719-13-4)

Safety Data

• Hazardous Substances Data: 1203719-13-4(Hazardous Substances Data)

Upstream product

• 697-73-4 2,6-difluorobenzyl chloride 
• 874774-61-5 C₁₁H₁₄F₂N₂ 
• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 

Relevant articles and documents

Design and Synthesis of Novel Insecticides Based on the Serotonergic Ligand 1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine(PAPP)

1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP) is a 5-HT1A agonist and was reported to display high affinity for serotonin (5-HT) receptor from the parasitic nematode Haemonchus contortus. The present investigation explored the possibility of using PAPP as a lead compound of new insecticides with novel mode of action. On the basis of the PAPP scaffold, a series of 1-arylmethyl-4-[(trifluoromethyl)pyridin-2-yl]piperazine derivatives were designed, synthesized, and evaluated for biological activities against the armyworm Pseudaletia separata (Walker). Bioassays showed that most of the target compounds displayed certain growth-inhibiting activities or larvicidal activities against armyworm. The quantitative structure-activity relationship (QSAR) for growth-inhibiting activities was also analyzed and established.