120375-57-7

Basic information

• Product Name: 6-Phenylhexylamine, Hydrochloride
• Synonyms: 6-Phenylhexylamine, Hydrochloride
• CAS NO: 120375-57-7
• Molecular Formula: C₁₂H₁₉N*ClH
• Molecular Weight: 213.7469
• Product Categories: Amines;Aromatics;Miscellaneous Reagents
• Mol File: 120375-57-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 283°C at 760 mmHg
• Flash Point: 122.7°C
• Appearance: /
• Vapor Pressure: 0.00324mmHg at 25°C
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 6-Phenylhexylamine, Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Phenylhexylamine, Hydrochloride(120375-57-7)
• EPA Substance Registry System: 6-Phenylhexylamine, Hydrochloride(120375-57-7)

Safety Data

• Hazardous Substances Data: 120375-57-7(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

6-Phenylhexylamine Hydrochloride (cas# 120375-57-7) is a compound useful in organic synthesis.

InChI:InChI=1/C12H19N.ClH/c13-11-7-2-1-4-8-12-9-5-3-6-10-12;/h3,5-6,9-10H,1-2,4,7-8,11,13H2;1H

Upstream product

• 138619-78-0 2-(6-phenylhexyl)-1,3-dihydro-1,3-dioxo-2H-isoindole 
• 5581-75-9 6-phenylhexanic acid 
• 2430-16-2 6-phenyl-1-hexanol 

Relevant articles and documents

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies

Ceramides are lipid-derived intracellular messengers involved in the control of senescence, inflammation, and apoptosis. The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into sphingosine and fatty acid and, by doing so, regulates their signaling activity. AC inhibitors may be useful in the treatment of pathological conditions, such as cancer, in which ceramide levels are abnormally reduced. Here, we present a systematic SAR investigation of the benzoxazolone carboxamides, a recently described class of AC inhibitors that display high potency and systemic activity in mice. We examined a diverse series of substitutions on both benzoxazolone ring and carboxamide side chain. Several modifications enhanced potency and stability, and one key compound with a balanced activity-stability profile (14) was found to inhibit AC activity in mouse lungs and cerebral cortex after systemic administration. The results expand our arsenal of AC inhibitors, thereby facilitating the use of these compounds as pharmacological tools and their potential development as drug leads.

SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS

The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.