1203852-76-9

Basic information

• Product Name: C₁₅H₁₄BrN₃O₆
• Synonyms: C₁₅H₁₄BrN₃O₆
• CAS NO: 1203852-76-9
• Molecular Weight: 412.197
• Mol File: 1203852-76-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₄BrN₃O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₄BrN₃O₆(1203852-76-9)
• EPA Substance Registry System: C₁₅H₁₄BrN₃O₆(1203852-76-9)

Safety Data

• Hazardous Substances Data: 1203852-76-9(Hazardous Substances Data)

Upstream product

• 51605-32-4 Ethyl 5-Methyl-4-imidazolecarboxylate 
• 2965-22-2 methyl 2-fluoro-5-nitro-benzoate 
• 1203852-75-8 1-(2-(methoxycarbonyl)-4-nitrophenyl)-5-methyl-1H-imidazole-4-carboxylic acid ethyl ester 

Downstream Products

• 78755-81-4 flumazenil 

Relevant articles and documents

Preparation method of flumazenil

The invention discloses a preparation method of flumazenil, and belongs to the field of medicine synthesis. The method comprises the following steps: by taking 5-fluoro-2-nitrobenzoic acid as a raw material, carrying out condensation on 5-fluoro-2-nitrobenzoic acid and sarcosine ester, and then carrying out ring closing while reducing, so as to obtain 7-fluoro-3, 4-dihydro-4-methyl-1H-[1, 4] benzodiazepine-2, 5-diketone; and finally, carrying out halogenation and cycloaddition reaction to obtain flumazenil. According to the novel synthesis method of the flumazenil key intermediate 7-fluoro-3, 4-dihydro-4-methyl-1H-[1, 4] benzodiazepine-2, 5-diketone, provided by the invention, a green synthesis process is adopted, an intramolecular cyclization reaction is performed while a nitro group is reduced, and compared with a known flumazenil synthesis method, a strong oxidant, a highly toxic reagent (such as ethyl chloroformate) and the like are not needed, and the yield is higher.