2965-22-2

Basic information

• Product Name: METHYL 2-FLUORO-5-NITROBENZOATE
• Synonyms: METHYL 2-FLUORO-5-NITROBENZOATE;RARECHEM AL BF 0280;methyl 2-fluoro-5-nitrobenzenecarboxylate;5-nitro-2-fluorobenzoic acid methyl ester;4-Fluoro-3-(Methoxycarbonyl)nitrobenzene
• CAS NO: 2965-22-2
• Molecular Formula: C₈H₆FNO₄
• Molecular Weight: 199.14
• Mol File: 2965-22-2.mol
• Article Data: 19

Chemical Properties

• Melting Point: 49-51℃
• Boiling Point: 303℃
• Flash Point: 137℃
• Appearance: /Solid
• Density: 1.388
• Vapor Pressure: 0.000967mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: METHYL 2-FLUORO-5-NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-FLUORO-5-NITROBENZOATE(2965-22-2)
• EPA Substance Registry System: METHYL 2-FLUORO-5-NITROBENZOATE(2965-22-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2965-22-2(Hazardous Substances Data)

Usage

General Description

Methyl 2-fluoro-5-nitrobenzoate is a chemical compound with the molecular formula C8H6FNO4. It is a yellow solid at room temperature and is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. The compound is characterized by its strong nitro and ester groups, making it an important intermediate in the production of many fluorine-containing compounds. Additionally, the presence of the fluorine atom makes this compound a valuable tool in medicinal chemistry for the development of new drugs and pharmaceuticals. However, due to its potential for causing skin and eye irritation, it should be handled with care and proper safety precautions.

InChI:InChI=1/C8H6FNO4/c1-14-8(11)6-4-5(10(12)13)2-3-7(6)9/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 445-29-4 o-fluoro-benzoic acid 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 56741-33-4 5-amino-2-fluorobenzoic acid 
• 74-88-4 methyl iodide 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 80-48-8 methyl p-toluene sulfonate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 6307-82-0 2-chloro-5-nitro-benzoic acid methyl ester 

Downstream Products

• 56741-34-5 methyl 5-amino-2-fluorobenzoate 
• 943513-64-2 1-[3-(chloromethyl)-4-(morpholin-4-yl)phenyl]pyrrolidin-2-one 
• 845461-50-9 C₃₈H₄₃N₃O₅ 
• 852898-44-3 C₃₇H₄₃N₃O₅S 
• 943513-63-1 12-cyclohexyl-3-[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyloxy]-6,7-dihydro-5-oxa-7a-azadibenzo[a,e]azulene-9-carboylic acid methyl ester 
• 759456-60-5 (5-amino-2-morpholinophenyl)methanol 
• 1013071-74-3 1-(3-hydroxymethyl-4-morpholin-4-ylphenyl)pyrrolidin-2-one 
• 943513-30-2 5-amino-2-[(2-methoxyethyl)methylamino]benzoic acid methyl ester 
• 943513-31-3 {5-amino-2-[(2-methoxyethyl)methylamino]phenyl}methanol 
• 943513-32-4 4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester 
• 943513-58-4 1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one 
• 943513-56-2 1-cyclohexyl-2-{2-fluoro-4-[2-[(2-methoxyethyl)methylamino]-5-(2-oxopyrrolidin-1-yl)benzyloxy]phenyl}-1H-benzimidazole-5-carboxylic acid methyl ester 
• 4031-84-9 methyl 5-amino-2-(4-morpholino)benzoate 
• 280772-27-2 methyl 5-Nitro-2-[1-(pyridin-4-yl)piperidin-4-ylmethylamino]benzoate 

Relevant articles and documents

Proximity effects in the palladium-catalyzed substitution of aryl fluorides

(Chemical Equation Presented) The aryl fluoride bond has long been considered inert toward Pd-catalyzed insertion reactions. This paper reports for the first time that aryl fluorides bearing an o-carboxylate group can undergo Pd-catalyzed couplings. On th

HETEROARYL COMPOUNDS AS INHIBITORS OF PROGRAMMED NECROSIS PATHWAY, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the programmed necrosis pathway.

PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to MKK4 (mitogen-activated protein kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The MKK4 inhibitors selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7.