1204006-29-0

Upstream product

• 3760-54-1 1-pyrrolidinecarboxaldehyde 
• 201415-38-5 5-phenylbenzoxazole 
• 1323158-67-3 4-phenyl-2-(pyrrolidin-1-ylmethyleneamino)phenol 
• 1134-36-7 2-amino-4-phenylphenol 

Relevant academic research and scientific papers

Visible-light-triggered oxidative C-H aryloxylation of phenolic amidines; Photocatalytic preparation of 2-aminobenzoxazoles

Visible light efficiently mediates an intramolecular cyclization reaction of o-hydroxy-N-aryl-N,N-dialkylformamidines (phenolic amidines) leading to 2-aminobenzoxazole derivatives in the presence of only 1 mol% tris(2,2′-bipyridine)ruthenium(II) as a photoredox catalyst along with air as terminal oxidant. The protocol involves oxidative functionalization of an amidinic C-H bond to a C-O bond and affords excellent yields of products in a simple one-pot operation under mild conditions. The method represents the first example of an oxidative C-H aryloxylation reaction implementing visible-light-driven aerobic photoredox catalysis. Georg Thieme Verlag Stuttgart New York.

A metal-free route to 2-aminooxazoles by taking advantage of the unique ring opening of benzoxazoles and oxadiazoles with secondary amines

Toss an amine into the ring: A new metal-free protocol for the amination of oxazoles has been developed by using iodobenzene diacetate to couple various oxazoles with amines (see scheme). The reaction proceeds through a ring-opening and subsequent ring-closing pathway. The optimal conditions are very mild and the substrate scope is broad, producing a range of 2-aminooxazoles, an important pharmacophore with high bioactivity. Copyright

Silver-mediated direct amination of benzoxazoles: Tuning the amino group source from formamides to parent amines

Formamides or parent amines were used as an amino group source for the silver-mediated amination of benzoxazoles. Although reactions with formamides proceeded at high temperatures, the direct amination with amines took place under much milder conditions (