1204122-71-3

Upstream product

• 1204122-37-1 (2R)-2-cyclohexyl-2-hydroxy-2-phenylacetamide 
• 20585-39-1 (2R)-2-Cyclohexyl-2-hydroxy-2-phenylacetic acid 
• 1204122-69-9 8-(benzyloxy)-5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-{[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperidin-1-yl]ethyl}phenyl)ethyl]amino}ethyl]quinolin-2(1H)-one 
• 4335-77-7 cyclohexylmandelic acid 
• 1204122-61-1 2-[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperdin-1-yl]ethyl}phenyl)ethyl]-1H-isoindole-1,3(2H)-dione 
• 1204122-44-0 (R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol 
• 1204122-42-8 tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate 
• 1204122-40-6 (R)-cyclohexyl(phenyl)1H-1,2,4-triazol-3-ylmethanol 

Downstream Products

• 1204123-15-8 PF-04810097 

Relevant academic research and scientific papers

Molecular hybridization yields triazole bronchodilators for the treatment of COPD

A 1,2,4-triazole motif was employed as a bioisostere for the ester commonly used in muscarinic antagonists, and subsequent integrative conjugation to a β2 agonist quinolinone furnished a new class of bifunctional MABAs for the treatment of COPD. Medicinal chemistry optimization using the principles of 'inhalation by design' furnished a clinical candidate with desirable pharmacological, pharmacokinetic and biopharmaceutical properties.

Triazol Derivatives Useful For The Treatment of Diseases

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.