1204176-45-3Relevant articles and documents
Synthesis method of tofacitinib intermediate
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Paragraph 0014; 0016-0019, (2021/06/06)
The invention provides a synthesis method of a tofacitinib intermediate. According to synthesis of cis-(4-methylpiperidine-3-yl) methyl carbamate, (4-methylpiperidine-3-yl) methyl carbamate is taken as an initial raw material, samarium iodide is taken as a hydrogenation agent, and water is taken as a hydrogen source to generate the cis-(4-methylpiperidine-3-yl) methyl carbamate. The method provided by the invention has the advantages of few byproducts, simple operation, high product yield and purity, and small amount of three wastes, and has excellent economic and environmental benefits.
THE PRESENT INVENTION RELATES TO PROCESS FOR THE PREPARATION OF TOFACITINIB AND INTERMEDIATES THEREOF.
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, (2014/07/21)
The present invention relates to process for the preparation of tofacitinib and intermediates thereof.
3-Amino-piperadine derivatives and methods of manufacture
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Page 10, (2008/06/13)
This invention relates to 3-amino piperadine derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formulas (Ia) and (Ib) wherein R1, R2, R3/sub