1204343-01-0

Basic information

• Product Name: C₂₈H₃₈F₄N₂O₄S
• CAS NO: 1204343-01-0
• Molecular Weight: 574.68
• Mol File: 1204343-01-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₈F₄N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₈F₄N₂O₄S(1204343-01-0)
• EPA Substance Registry System: C₂₈H₃₈F₄N₂O₄S(1204343-01-0)

Safety Data

• Hazardous Substances Data: 1204343-01-0(Hazardous Substances Data)

Upstream product

• 1204386-90-2 C₁₆H₂₀F₄N₂O₆S 
• 1123172-99-5 ((3R,4S,5S)-5-(3,5-difluoro-4-nitrobenzyl)-4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-3-yl)carbamate 
• 1204344-07-9 C₂₁H₂₈F₄N₂O₈S 
• 6136-71-6 1-(3-(tert-butyl)phenyl)ethan-1-one 
• 1204344-04-6 C₂₁H₂₈F₄N₂O₇S 

Relevant articles and documents

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

Previous structure based optimization in our laboratories led to the identification of a novel, high-affinity cyclic sulfone hydroxyethylamine- derived inhibitor such as 1 that lowers CNS-derived Aβ following oral administration to transgenic APP51/16 mice. Herein we report SAR development in the S3 and S2′ subsites of BACE1 for cyclic sulfoxide hydroxyethyl amine inhibitors, the synthetic approaches employed in this effort, and in vivo data for optimized compound such as 11d.